No abstract

No abstract

No abstract

Background: Malignant lymphoma is the most common hematological malignancy accounts for approximately 8% of all adult malignancies. Lymphomas are broadly divided into Hodgkin lymphoma and non-Hodgkin's lymphoma. Non-Hodgkin lymphoma accounts for about 5% of all cases of cancer. Non-Hodgkin lymphomas have the vast majority of cases and have a greater predilection to disseminate to extranodal sites. Aim of Study: The aim of this work is to study the role of PET/CT in the diagnosis and follow-up of Non-hodgkin lymphoma and assess its extranodal extention. Patients and Methods: The study was conducted on thirty patients where the diagnosis of non-hodgkin lymphoma have been pathologically confirmed, 18 males (60%) and 12 females (40%), their ages are ranged between 19 to 73 years old. All patients were subjected to full history taking, laboratory testing, biopsy and histopathology, the studied cases according to pathalogical type of non-Hodgkin lymphoma mostly were of B-cell type (80%) and (20%) T-cell type, CT scan and PET/CT examination. All patients were examined using Siemens Bio-graph true point PET/CT scanner. Results: Extranodal involvement was detected by PET/CT in 16 patients (53.3%). Their distribution was as follows; head and neck: 4 patients (13.3%), lung: 3 patients (10%), abdomen: 12 patients (40%), MSK: 10 patients (33.3%), while CECT detected 8 patients had extra nodal involvement their distribution was as follow; head and neck: 2 patients (6.6%), lung: 1 patient (3.3%), abdomen:7 patients (43.7%), MSK: 6 patients (16.6%). Thirty patients referred for initial assessment SUV max among the 30 patients referred for initial assessment ranged from 3.7-34.0 with mean value of 16.91 ± 8.07 SD. In aggressive type of NHL SUVmax ranged from 10.5-34.0 with mean value of 19.9 ±6.65 SD, the aggressive type of NHL is significantly higher (p≤ 0.01) than in indolent type.

Purpose The purpose of this study is to assess the corpus callosum microstructural changes in children with memory related learning disability. Methods DTI was performed in 20 patients with memory related learning disabilities (MRLD +) and 22 matched healthy control subjects (MRLD -) aged 7– 13 years. Fractional anisotropy (FA), axial diffusivity, radial diffusivity (RD) and trace were calculated for corpus callosum. Comparison between patients with memory related learning disabilities (MRLD +) and healthy control subjects (MRLD -) was performed. DTI metrics were correlated to clinical digit span backward scores in (MRLD +) group. A pvalue less than .05 was considered significant. Results The corpus callosum showed a highly significant higher FA and lower diffusivity indices in (MRLD +) group compared to the (MRLD -) group (p < 0.001). No significant correlation between the clinical test “digit span backward” scores and DTI metrics of the corpus callosum was found. Conclusion Changes in DTI metrics of corpus callosum in patients with memory related learning disabilities reflects white matter micro-structural changes. Higher FA values and lower diffusivity indices do not necessarily indicate healthier white matter but, can indicate pathology.