We describe two Japanese girls with discoid lupus erythematosus (DLE) in whom the condition showed a linear configuration following the lines of Blaschko. The clinical appearance was unusual but histological examination established the diagnosis. After reviewing the previous reports, we found that in six of eight patients with linear 'discoid' lesions, the age at onset was under 14 years; no patient has progressed to systemic lupus erythematosus. Patients with 'linear' DLE may compose a certain clinical subset. We propose the term 'linear cutaneous lupus erythematosus' which may be more suitable for the linear lesions of DLE.

Tryptase increases not only the proliferation of human dermal fibroblasts but also type I collagen production.

Guest Editor's Introduction: This paper was presented at the 26th ASAIO Congress held in April 1980. It was printed in Trans. Am. Soc. Artif. Intern Organs, Volume 26, page 406–411, 1980, and reprinted here with permission. This is the first clinical paper dealing with double filtration plasmapheresis. The plasma separator was made using Kuraray's polyvinyl alcohol hollow fiber, and Kuraray's plasma fractionator was made of ethylene vinyl alcohol hollow fibers. Seven patients afflicted with various diseases were treated by this method for 2 to 10 sessions. This procedure required supplemental infusion of albumin solution.

Angioimmunoblastic T-cell lymphoma (AILT) and peripheral T-cell lymphoma, unspecified (PTCL-u) are relatively frequent subtypes of T-or natural killer cell lymphoma. To characterize the structural anomalies of chromosomes associated with these disorders, we here determined chromosome copy number alterations (CNAs) and loss of heterozygosity (LOH) at 455 000 single nucleotide polymorphism loci for clinical specimens of AILT (n ¼ 40) or PTCL-u (n ¼ 33). Recurrent copy number gain common to both conditions was detected on chromosomes 8, 9 and 19, whereas common LOH was most frequent for a region of chromosome 2. AILT-or PTCL-uspecific CNAs or LOH were also identified at 21 regions, some spanning only a few hundred base pairs. We also identified prognosis-related CNAs or LOH by several approaches, including Cox's proportional hazard analysis. Among the genes that mapped to such loci, a poor prognosis was linked to overexpression of CARMA1 at 7p22 and of MYCBP2 at 13q22, with both genes being localized within regions of frequent copy number gain. For a frequent LOH region at 2q34, we also identified IKAROS family zinc-finger 2 cDNAs encoding truncated proteins. Our data indicate that AILT and PTCL-u consist of heterogeneous subgroups with distinct transforming genetic alterations.

We have found a thermal hysteresis in the photoresponsivity of a Langmuir film for the first time. The Langmuir film of an amphiphilic spiropyran, 1',3'-dihydro-3',3'-dimethyl-6-nitro-1'-octadecyl-8-(docosanoyloxymethyl)spiro[2H-1-benzopyran-2,2'-(2H)-indole] (SP) was fabricated at 13 degrees C at 10 mN m-1, followed by heating to a given temperature. UV irradiation of this film caused only the isomerization of SP to the corresponding merocyanine (MC) up to 29 degrees C. Light-induced J-aggregation of MC occurred at 30 degrees C. On the other hand, once the film was heated to 30 degrees C, light-induced J-aggregation was observed down to 27 degrees C. The hysteresis should be related with the phase transitions that occur in the bulk of SP at similar temperatures. No significant morphological change occurred by light-induced J-aggregation in the Langmuir-Blodgett (LB) film of SP by the present method, in contrast to the case of the LB films fabricated under isothermal conditions at 30 degrees C. This feature enabled us to pattern the LB film with J-aggregate of MC by UV irradiation through a photomask of lines with a width of 5 mum each.

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An improved search for a T-violating transverse muon polarization ͑P T ͒ in K 1 ! p 0 m 1 n decay was performed using kaon decays at rest. By means of this method, P T was extracted with small systematic errors, P T 20.0042 6 0.0049͑stat͒ 6 0.0009͑syst͒, and the T-violation parameter was determined to be Imj 20.013 6 0.016͑stat͒ 6 0.003͑syst͒.The transverse muon polarization ͑P T ͒ in the K 1 ! p 0 m 1 n decay ͑K 1 m3 ͒ is the polarization component normal to the decay plane, and is a T -odd observable defined by the correlation of the p 0 and m 1 momentum vectors p p 0 and p m 1 and the m 1 spin s m , as P T s m ? ͑p p 0 3 p m 1 ͒͞jp p 0 3 p m 1 j. A nonzero value would be evidence for violation of time reversal invariance ͑T ͒ [1], since any spurious effect from final state interactions is known to be small [2]. Moreover, because the contribution to P T from the standard model (SM) is as small as 10 27 [3], P T would provide important clues to new physics beyond the SM, or in particular, to a CP-violation mechanism from non-SM origins [4] assuming CPT invariance. It is in contrast to the SM T -violation recently observed in the neutral kaon system [5]. The previous limit of P T along with that from K 0 L ! p 2 m 1 n decay ͑K 0 m3 ͒ come from Brookhaven National Laboratory (BNL) experiments [6,7] to obtain the T -violation physics parameter, Imj 20.016 6 0.025 ͑K 1 m3 ͒ and Imj 0.009 6 0.030 ͑K 0 m3 ͒, where j is defined as the ratio of two form factors, f 1 ͑q 2 ͒ and f 2 ͑q 2 ͒ [8].In this Letter we report an improved search for P T . The present experiment (KEK E246) uses stopped K 1 as opposed to the previous BNL experiment [6] which used in-flight decay. The decay products are emitted in all directions and detected with a setup in a 12-sector superconducting toroidal magnet (Figs. 1a and 1b). P T is measured as the azimuthal ͑f͒ polarization of m 1 emitted radially ͑r͒ when a p 0 is tagged in the forward (fwd) or the backward (bwd) direction relative to the detector ͑z͒ axis. The signature of nonzero P T is an asymmetry between clockwise (cw) and counterclockwise (ccw) Michel e 1 (Fig. 1c). Summation over the twelve sectors plays an important role in reducing systematic error. For finite P T , events from fwd and bwd p 0 's have opposite asymmetries. By taking their difference, the P T signal is doubled and most systematic errors are reduced.A separated K 1 beam ͑p 1 ͞K 1 ഠ 6͒ of 660 MeV͞c was produced at the 12 GeV proton synchrotron with a 0031-9007͞99͞83(21)͞4253(4)$15.00