The emergence of the crisis in Sudan has led to an overstretched healthcare system therein, which has negatively impacted the public health system of the nation. The WHO has noted the closure of roughly sixteen hospitals since the start of the conflicts due to staff safety concerns as well as a shortage of hospital supplies, consumables, and medication. Due to ongoing conflicts and persistent political instability, Sudan receives very little funding from donor organizations to maintain its healthcare system, which worsens the nation’s general public health architecture. Thus, amidst the ongoing crisis recent floods in the country can further pose serious challenges like disease outbreaks, starvation, infectious diseases, deteriorating health infrastructure, and mental health issues. To successfully reduce the severity of negative impacts on public health, the crisis must be ceased and facilities reopened. A well-structured disease surveillance system for infectious diseases should be established, pregnant women and children under the age of five should be treated for free, and mental health awareness and examination should be prioritized. The global community must act expeditiously to mitigate the devastating effects of this crisis.
Background Alysicarpus glumaceus has been reported to be used in managing patients with neuropsychiatric disorders. This work aimed to determine the behavioural effects of aerial parts of Alysicarpus glumaceus in murine models. Method The behavioural effects of the drug extract was evaluated using elevated zero maze (EZM), stair case test (SCT) and the open field test (OFT) while beam walking was used to test for motor coordination deficit and stimulant activity in mice at doses of 500, 1000 and 1500 mg/kg using diazepam (0.05 mg/kg) as the standard and normal saline (NS) as the control. Results All the test doses of the extract reduced the stretch attend posture and head dips as well as the number of rearing without significant decrease in the number of stairs climbed in the EZM and SCT respectively when compared to NS. In the OFT, Alysicarpus glumaceus extract increased the number of square crossing but it was insignificant (p>0.05). The extract at 1000 and 1500 mg/kg significantly (p<0.01) decreased the number of rearing; while at 500 mg/kg it significantly (p<0.001) decreased the number of rearing. At all the test doses used, there was no significant difference in time to reach the goal box and number of foot slips, however, mice given 500 mg/kg of the extract produced a significant (p<0.05) increase in time spent on the beam. Conclusion The findings revealed that the aerial parts of Alysicarpus glumaceus possesses central nervous system depressant actions.
The World Health Organization (WHO) has launched campaigns to boost immunization rates to 70 percent globally by the middle of 2022. However, despite the global success of about 64% COVID-19 vaccination coverage, there is a big gap in Nigeria. To date, only 13.8% of the population has received the recommended dose. This demonstrates a significant disparity between the vaccinated and the unvaccinated. Amidst the wide gap in vaccination, COVID-19 vaccine wastage still occurs in Nigeria. At the end of 2021, it was estimated that over a million doses of the COVID-19 vaccine had been wasted. It is anticipated that there will be more COVID-19 vaccine wastage in Nigeria, because of the combined factors that threaten vaccination uptake including vaccine hesitancy, lack of appropriate storage facilities, poor electricity supply, insecurity challenges, and inadequate health promotion. This results in concomitant financial and opportunity losses. In this paper, we discuss COVID-19 vaccine wastage in Nigeria including causes, and solutions that can be applied to mitigate this wastage.
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