Prostate cancer is one of the most common cancer worldwide, where South Sulawesi is included in four provinces with the highest prevalence of prostate cancer in Indonesia. Laboratorium Sentra Patologia Makassar (SDPM) stated that prostate cancer cases continue to rise each year. Androgen receptor (AR) plays a role in the growth and differentiation of male urogenital structures, both under normal and neoplastic conditions, the neoplastic condition is caused by the mechanism of the AR pathway which undergoes changes that continue in the development and progression of prostate lesions, both benign and malignant. Androgen receptors are generally found evenly distributed in the nuclei of glandular and stromal cells in prostate hyperplasia and vary widely in prostate cancer. These inventions show that AR inhibitors are used to treat prostate adenocarcinoma by inhibiting androgen synthesis. Assessment of AR expression can be used in determining therapy and predicting the success of hormonal therapy so that the prognosis of the disease is better. This study is conducted to learn more about AR expression in adenocarcinoma prostate grading. The type of this research is an observational analytical study with cross-sectional methods. Samples are taken based on consecutive sampling of as many as 77 respondents. There is a significant difference between AR expression score and histopathological feature of prostate adenocarcinoma WHO Grup Grade (p<0,001). In conclusion, there is a significant correlation between AR and WHO Grup Grade and could be used as important marker in grading adenocarcinoma prostate progression
Keywords : Androgen receptor (AR); prostate adenocarcinoma; WHO Grup Grade
Stunting may have occurred since prenatal phases until the baby was 2 years old because of malnutrition. Children having stunting have a problem in growth and cognitive impairments. This study aims to analyze the risk factors of stunting among children under five in Empagae, Sidrap Regency. This correlational research study the correlation between posyandu visits, health workers' roles, and parenting on stunting. Technique sampling used was consecutive sampling with 52 respondents. The results showed that there was a moderate correlation between the health workers roles and stunting (p-value = 0.018; r = 0.33), strong correlation between parenting styles and stunting (p. -value = 0.000; r = 0.82), and moderate correlation between posyandu visits stunting (p-value = 0.002; r = 0.43). This research implies that mothers must fulfill nutrition to prevent stunting and be more active in posyandu activities to have nutrition monitoring. It is hoped that health workers have to control and monitor the nutritional status of toddlers, pregnant women, and mothers who have babies to prevent stunting.
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