Background: Parasitic protozoa and helminthes are responsible for some of the most devastating and prevalent diseases of humans, threatening the lives of nearly one-third of the worldwide human population leading to more than 2 million deaths annually. Objective: determine serum total cholesterol [T.C], triglycerides [TG], high-density lipoprotein cholesterol [HDL-C] and low-density lipoprotein cholesterol [LDL-C] in patients infected with Schistosoma haematobium. Materials: A cross-sectional study was conducted in Sudan between August, 2011 and January, 2013. The study included 250 infected subjects with Schistosoma haematobium[males and females] and 100 volunteers apparently healthy as control. All participants aged 7-12 years. Methods: The concentration of Total Cholesterol, Triglyceride LDL and HDL were measured using direct kit methods, and detection of urinary schistosoma haematobium eggs was carried by microscopy. Results: The mean concentration of triglyceride, total cholesterol, high density lipoprotein cholesterol [HDL-C] and low density lipoprotein cholesterol [LDL-C] were significantly lower among S. haematobium-infected subjects than in controls irrespective of the age and sex Triglyceride and Cholesterol was significantly low when the concentrations ofova in urine was high [>50], and only the cholesterol was significantly low in female patients compared to males. Conclusion: This study showed that schistosoma infection made significant alteration in plasma lipid levels with a corresponding increase in parasitemia levels in urine.