This study was designed to note the preventive effect of Utrica dioica aqueous extract (100 mg / kg of body weight) in healthy white male rats exposed to copper sulfate poisoning (40 mg / kg bw) throughout the 30day treatment period, and the weights ranged between 240-260 g and their ages are between 2-3 months, and the animals were divided randomly into four groups, each group containing 7 rats. Results showed that when Utrica dioica extract was administered, it led to a significant decrease of P < 0.05 in cholesterol concentration and a significant increase in high-density lipoprotein (HDL) and no significant difference in organ weights, glucose, uric acid, urea, creatinine, triglycerides, low-density lipoprotein (LDL) and Very low-density lipoprotein (VLDL) compared to the control group. When animals were given copper sulfate, it led to a significant decrease in body weight, and a significant increase in weights (liver, kidney and spleen), glucose, uric acid, urea, creatinine, TG and LDL triglycerides, and it did not differ significantly in cholesterol, HDL and VLDL compared with the control group. When administering (Utrica dioica + copper), it led to a significant decrease in kidney weight, glucose, uric acid, urea, creatinine, triglycerides and LDL, and a significant increase in body weight and HDL while it did not significantly differ in cholesterol and VLDL from compared with the group that was given Copper sulfate. It is concluded from the study that the Utrica dioica extract had positive effects in animals exposed to copper sulfate poisoning.
This study was aimed to search the effect of Camel milk on males albino mice exposed to ferrous sulfate toxic 30 mg / kg body weight for period 30 days. The animals were randomly divided into 3 groups, each group comprising 5 animals that weigh 26-27 gm. The results of oral dose were shown with ferrous sulfate a significant decrease in (P <0.05) in body weight, MON, GRAN, HCB, HCT. And significant increase (P<0.05) in kidney, spleen, LYM, MCHC, AST, ALT, Urea. And no significant difference in the heart, liver, WBC, RBCs, MCV, MCH, Protein and Albumin compared with the control group. As for the results of oral dosage of Camel’s milk + ferrous sulfate appeared a beneficial effect of these values compared to the group given ferrous sulfate. The oral dose of ferrous sulfate causes pathological histopathological changes in the kidneys and liver of male mice. The tissue is Separation of central venous wall from Hepatocyte and the Existence of congestion in the liver and Clear hemorrhage within the kidney tissue with a clear contraction of renal glomerulosclerosis in the kidneys. The treatment with Camel’s milk + ferrous sulfate showed the return of central vein and hepatocytes to a semi-natural condition with congestion remaining within the central vein in the liver and showing Glomerulus and urinary tubules are almost normal in the kidneys. Showed an effect to reduce damage or damage completely in certain areas of the tissue compared to ferrous sulfate group.
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