The effect of aqueous Urtica dioica extract in male rats exposed to copper sulfate poisoning

Abstract

This study was designed to note the preventive effect of Utrica dioica aqueous extract (100 mg / kg of body weight) in healthy white male rats exposed to copper sulfate poisoning (40 mg / kg bw) throughout the 30day treatment period, and the weights ranged between 240-260 g and their ages are between 2-3 months, and the animals were divided randomly into four groups, each group containing 7 rats. Results showed that when Utrica dioica extract was administered, it led to a significant decrease of P < 0.05 in cholesterol concentration and a significant increase in high-density lipoprotein (HDL) and no significant difference in organ weights, glucose, uric acid, urea, creatinine, triglycerides, low-density lipoprotein (LDL) and Very low-density lipoprotein (VLDL) compared to the control group. When animals were given copper sulfate, it led to a significant decrease in body weight, and a significant increase in weights (liver, kidney and spleen), glucose, uric acid, urea, creatinine, TG and LDL triglycerides, and it did not differ significantly in cholesterol, HDL and VLDL compared with the control group. When administering (Utrica dioica + copper), it led to a significant decrease in kidney weight, glucose, uric acid, urea, creatinine, triglycerides and LDL, and a significant increase in body weight and HDL while it did not significantly differ in cholesterol and VLDL from compared with the group that was given Copper sulfate. It is concluded from the study that the Utrica dioica extract had positive effects in animals exposed to copper sulfate poisoning.

Protective Role of Ankaferd Blood Stopper on Cadmium-Induced Acute Nephrotoxicity

“…Siouda et al showed the renal protective effects of Urtica dioica against HgCl2 administration by measuring serum urea, creatinine levels, and kidney glutathione (GSH) levels, (29). Similarly, in 2021, Aldulaimi et al showed that Urtica dioica treatment against copper sulfate toxicity caused a decrease in high serum urea and creatinine levels (30). Although these studies are not sufficiently detailed, they may be considered as remarkable as they reflect the renoprotective effects of Urtica dioica in heavy metal poisoning.…”