Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one -way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals.
Non-communicable diseases are severe world health problems mainly in sab Saharan-African countries developing countries including Ethiopia. Cardiovascular diseases are one of the major non-communicable diseases increase with rises of hypertension. Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. A billion people affected globally and millions of them deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used for treatments hypertension. Psidium guava is one popular medicinal plant which is widely used in traditional medicine treatment of different diseases such as diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify the effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on eight male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive methods. The result was analyzed by using independent student t test and one way ANOVA. Ethanol extract of P. guava leaf showed a significant (p=0.05, p=0.001) reduction of blood pressure of in normotensive guinea pigs in dose dependent manner. The effect of P. guava leaf extract in reduction of blood pressure is may be due to a number of phytochemical contents.
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