The Effect of ethanol Psidium Guava leaf extract on KCl Induced Contracted Aortic tissues of Guinea Pigs

Abstract

Hypertension is elevation of systolic blood pressure greater than or equal to 140 mm Hg and/or diastolic blood pressure greater than or equal to 90 mm Hg. It affects 1 billion people and accounts for approximately 7.1 million deaths annually. It is significant risk factor for cardiovascular disorders. Some medicinal plants are traditionally used to treat hypertension. Psidium guava is one of widely cultivated medicinal plant used as traditional medication for diabetes, vomiting, diarrhea and dyslipidemia. The study was designed to identify effect of P. guava leaf extract on hypertension in guinea pigs. The study was conducted on six male guinea pigs to measure the effect of ethanol P. guava leaf extract by using invasive method. The result was analyzed by using paired t-test, independent student t test, one -way ANOVA. Ethanol extract of P. guava leaf showed a significant (p= 0.001) ability to relax isolated aortic tissue of guinea pigs in dose dependent manner, after induction of aortic muscle contraction by high potassium chloride concentrations (80 mM KCl). The effects of P. guava leaf extract in relaxation contracted aortic tissue was may be due to numerous effect of phytochemicals.

Exploration of Medicinal Phyto-Diversity of the Semi-Arid Area in Punjab Province, Pakistan

“…Mishra et al, (Mishra et al, 2010), reported that Albizzia lebbeck bark have anti-asthmatic, anti-anaphylactic properties and pods have analgesic, anxiolytic, antiinflammatory, anti-diarrheal activities and antispermatogenic effect Sheyin et al, 2015). The Psidium guajava broadly studied for antimicrobial (Mendez et al, 2016), against diabetes (Joseph et al, 2016), anti-inflammatory (El-Ahmady et al, 2013), anti-tumor, anti-cancer (Ashraf et al, 2016), for diabetes, vomiting, diarrhea and dyslipidemias (Elias et al, 2017) and leaves aqueous extracts of Psidium guajava use for obesity and dyslipidemias (Simao et al, 2017). These outcomes ratify high UV and RFC index of above stated medicinal plants in district Faisalabad.…”

Effect of Leaf Guava Extract on Blood Pressure in Rattus Norwegicus Wistar Strain

“…Penggunaan daun jambu biji sebagai obat tradisional di Indonesia untuk berbagai macam penyakit seperti sariawan, batuk, diare, sembelit, luka, haid tidak lancar, kanker, maag, masuk angin, flu dan demam berdarah namun lebih dari itu dalam daun jambu biji diketahui mengandung pektin yaitu serat larut air yang berfungsi dapat menurunkan kadar kolesterol (Diana et al, 2021;Rahayu et al, 2016). Penelitian menggunakan ekstrak etanol P.guava secara signifikan dapat menurunkan tekanan darah (Elias et al, 2017). Hasil penelitian ini sejalan dengan beberapa penelitian terdahulu.…”

“…P.guajava juga memiliki anti diare dan aktivitas antimikroba (Ezekwesili et al, 2010). Efek menguntungkan pada P.guajava kemunkinan berkaitan dengan kandungan zat gizi dan zat nongizi seperti vitamin C, vitamin A, zat besi, kalsium, mangan, posfor, oksalat, dan asam malac, saponin kombinasi dengan oleanolic (Elias et al, 2017).…”

“…Pengobatan menggunakan tumbuhan mengandung sejumlah komponen aktif dalam pencegahan sejumlah penyakit. Produk herbal bekerja secara individual, sinergis dan kemungkinan juga sinergis dengan pengobatan modern (Elias et al, 2017).…”