A 2-minute intravenous injection of daptomycin in this patient yielded a reaction that was not present on rechallenge with standard, extended infusion.
The infrared spectra of gaseous and solid 1, 1-dibromoethane and 1, 1-dibromoethane-d4 have been recorded from 140 to 3500 cm−1. The corresponding Raman spectra of the liquid and solids have also been recorded and depolarization values have been measured. All spectra have been interpreted in detail and the 18 normal vibrations have been characterized on the basis of band contours, isotopic shifts, depolarization values, and normal coordinate calculations. The internal torsional mode was observed at 253 cm−1 in the far infrared spectrum of gaseous CH3CHBr2 and the assignment was confirmed by the shift with deuteration. The threefold barrier to rotation was calculated to be 4.3 kcal/mole. This determination allows a comparison of the barriers for a series of bromoethanes.
The infrared spectra of gaseous and solid 1,1-dichloroethane and 1, l-dichloroethane-dt have been recorded from 140 to 4000 cm"1. The corresponding Raman spectra of the gases and liquids have also been recorded and depolarization values have been measured. All spectra have been interpreted in detail and the 18 normal vibrations have been characterized on the basis of the band contours, isotopic shifts, depolarization values, and normal coordinate calculations. The internal torsional mode was observed at 196 cm"1 in the infrared spectrum of solid CD3CDCI2. The threefold barrier to rotation was calculated to be 4.77 kcal/mol. This value is compared to those reported for other chloroethanes.
Implementation of a standardized dosing nomogram reduced the amount of daptomycin wasted and resulted in cost savings. The standardized dosing nomogram did not impair the rate of clinical effectiveness or cause adverse events.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.