Infusion-Related Reaction following Daptomycin Two-Minute Rapid Intravenous Administration

Caulder, Celeste R.; Sloan, Aaron; Ahmed, Yasir; Bookstaver, P Brandon

doi:10.1310/hpj4907-644

Cited by 6 publications

(8 citation statements)

References 6 publications

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“…At the outset of this study, the initial antibacterial screening was performed on methicillinresistant Staphylococcus aureus (MRSA, 2658 RCMB). The results presented in Table 1 indicated that the 2-amino-1,3,4oxadiazole linker with aliphatic side chains (compounds [8][9][10][11][12][13][14][15][16][17] is void of anti-MRSA activity.…”

Section: Biological Results and Discussionmentioning

confidence: 99%

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tert-Butylphenylthiazoles with an oxadiazole linker: a novel orally bioavailable class of antibiotics exhibiting antibiofilm activity

et al. 2019

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The structure-activity and structure-kinetic relationships of a new tert-butylphenylthiazole series with oxadiazole linkers were conducted with the objective of obtaining a new orally available antibacterial compounds. Twenty-two new compounds were prepared, purified and identified. Their activity against methicillin-resistant Staphylococcus aureus were examined. Compound 20 with 3-hydroxyazetidine as a nitrogenous side chain showed promising activity against twenty-four clinical isolates, including vancomycin-resistant staphylococcal and enterococcal species with MIC values ranging from 4-8 mg mL À1 . Additional advantages of this compound include an ability to eradicate staphylococcal biofilm mass in a dose-dependent manner as well as high metabolic stability after an oral dose of 25 mg kg À1 with a biological half-life that exceeds 5 hours and a plasma concentration (C max ) that exceeds the MIC values.

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Section: Biological Results and Discussionmentioning

confidence: 99%

“…So far, most of the newly-introduced antibiotics, such as cearoline 16 and lipoglycopeptides are taken parenterally. 17 When phenylthiazoles were rst discovered, their main drawback was the extremely short plasma half-life of the early generation, for which the t 1/2 of the lead compound 1 (Fig. 1) was only 29 minutes.…”

Section: 23mentioning

confidence: 99%

tert-Butylphenylthiazoles with an oxadiazole linker: a novel orally bioavailable class of antibiotics exhibiting antibiofilm activity

et al. 2019

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“…A case report previously described erythroderma developing 2 hours after the first 650 mg dose (6 mg/kg) of daptomycin given as a 2-minute infusion. 9 The reaction included redness and warmth around the face next and upper back 2 hours after the infusion. On further administration, erythroderma did not recur.…”

Section: Discussionmentioning

confidence: 99%

“…Any patient with a potential IRR was assessed and scored using the Naranjo algorithm. 10 All identified IRRs were adjudicated blinded to administration method by 2 clinical pharmacy specialists.…”

Section: Methodsmentioning

confidence: 99%

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High-Dose Daptomycin Is Well Tolerated via 2-Minute IV Push Administration

et al. 2020

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Background: The purpose of this study was to evaluate the safety of administering high-dose daptomycin (HDD; > 6 mg/kg actual body weight) as a 2-minute intravenous (IV) push (IVP) compared to traditional 30-minute IV piggyback (IVPB) infusion. Methods: Retrospective cohort study comparing patients receiving HDD as an IVP or IVPB infusion. The primary outcome was the proportion of patients with a documented infusion-related reaction (IRR) to daptomycin. Results: Three hundred patients were included in the final analysis, 200 patients received IVP, and 100 patients received IVPB representing a total of 1697 administrations. Median (IQR) daptomycin dose was IVP 700 mg (550-900) and IVPB 700 mg (600-900), with mg/kg doses of 8.2 (7.9-10) and 8.3 (8-10), respectively. After adjudication, IRR occurred in 1% of subjects in each treatment group. Conclusions: This study provides data in more than 1100 administrations of HDD administered via IVP. Infusion-related reactions were documented in 1% of patients regardless of infusion method, suggesting comparable safety to traditional infusion methods. This practice may be useful during fluid shortage and in the outpatient setting.

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Daptomycin

2014

Reactions Weekly

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Infusion-Related Reaction following Daptomycin Two-Minute Rapid Intravenous Administration

Abstract: A 2-minute intravenous injection of daptomycin in this patient yielded a reaction that was not present on rechallenge with standard, extended infusion.

Cited by 6 publications

References 6 publications

tert-Butylphenylthiazoles with an oxadiazole linker: a novel orally bioavailable class of antibiotics exhibiting antibiofilm activity

tert-Butylphenylthiazoles with an oxadiazole linker: a novel orally bioavailable class of antibiotics exhibiting antibiofilm activity

High-Dose Daptomycin Is Well Tolerated via 2-Minute IV Push Administration

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