In drug discovery applications, high throughput virtual screening exercises are routinely performed to determine an initial set of candidate molecules referred to as "hits". In such an experiment, each molecule...
For the first time, an inclusion
complex has been crafted between
a carbohydrate-based molecule and a β-cyclodextrin (CD) hydrophobic
cavity for asymmetric catalytic applications. This novel d-glucosamine-based inclusion compound has been synthesized in high
yields using an innovative and proficient acoustic cavitation technology
and well characterized using various techniques, such as infrared
spectroscopy, nuclear magnetic resonance spectroscopy, ultraviolet–visible
spectroscopy, thermogravimetric analysis, scanning electron microscopy,
and other spectroscopic techniques. It was observed that the inclusion
of a d-glucosamine derivative into the hydrophobic cavity
of β-CD increased its surface area and thermal stability. This
catalytic system worked well in water for the direct aldol reaction
to afford the products in excellent yields with high diastereo- and
enantioselectivities.
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