Известия Национальной академии наук Республики Казахстан 2 NAS RK is pleased to announce that News of NAS RK. Series of chemistry and technologies scientific journal has been accepted for indexing in the Emerging Sources Citation Index, a new edition of Web of Science. Content in this index is under consideration by Clarivate Analytics to be accepted in the Science Citation Index Expanded, the Social Sciences Citation Index, and the Arts & Humanities Citation Index. The quality and depth of content Web of Science offers to researchers, authors, publishers, and institutions sets it apart from other research databases. The inclusion of News of NAS RK. Series of chemistry and technologies in the Emerging Sources Citation Index demonstrates our dedication to providing the most relevant and influential content of chemical sciences to our community. Қазақстан Республикасы Ұлттық ғылым академиясы "ҚР ҰҒА Хабарлары. Химия жəне технология сериясы" ғылыми журналының Web of Science-тің жаңаланған нұсқасы Emerging Sources Citation Index-те индекстелуге қабылданғанын хабарлайды. Бұл индекстелу барысында Clarivate Analytics компаниясы журналды одан əрі the Science Citation Index Expanded, the Social Sciences Citation Index жəне the Arts & Humanities Citation Index-ке қабылдау мəселесін қарастыруда. Webof Science зерттеушілер, авторлар, баспашылар мен мекемелерге контент тереңдігі мен сапасын ұсынады. ҚР ҰҒА Хабарлары. Химия жəне технология сериясы Emerging Sources Citation Index-ке енуі біздің қоғамдастық үшін ең өзекті жəне беделді химиялық ғылымдар бойынша контентке адалдығымызды білдіреді. НАН РК сообщает, что научный журнал «Известия НАН РК. Серия химии и технологий» был принят для индексирования в Emerging Sources Citation Index, обновленной версии Web of Science. Содержание в этом индексировании находится в стадии рассмотрения компанией Clarivate Analytics для дальнейшего принятия журнала в the Science Citation Index Expanded, the Social Sciences Citation Index и the Arts & Humanities Citation Index. Web of Science предлагает качество и глубину контента для исследователей, авторов, издателей и учреждений. Включение Известия НАН РК в Emerging Sources Citation Index демонстрирует нашу приверженность к наиболее актуальному и влиятельному контенту по химическим наукам для нашего сообщества.

The article presents literature review on the physicochemical and biological properties of fullerene C60, as well as the authors' own experimental data on the synthesis of fullerene derivatives of amines and natural alkaloids. It is shown that the presence of a fullerene fragment in the structure of the compound provides a significant improvement or the appearance of qualitatively new mechanical, chemical, physical, biological and other properties associated with the manifestation of nanoscale factors. The issues of the relationship of the structure, water solubility and biological activity of fullerene С60 derivatives are considered. Many biologically active effects of various modified derivatives of fullerene C60 are described, which have membrane-active, antibacterial, antiviral, immunomodulating, HIV inhibitory enzymes and other properties. It was noted that preparations containing a fullerene fragment are effective against hepatitis C virus, and are also able to efficiently trap free radicals. Derivatives of fullerenes can also be used as antioxidant, neuroprotective and other agents. Particular attention is paid to the authors' own results on the synthesis of amino derivatives of fullerenes.

News of the Academy of sciences of the Republic of Kazakhstan 2 NAS RK is pleased to announce that News of NAS RK. Series of chemistry and technologies scientific journal has been accepted for indexing in the Emerging Sources Citation Index, a new edition of Web of Science. Content in this index is under consideration by Clarivate Analytics to be accepted in the Science Citation Index Expanded, the Social Sciences Citation Index, and the Arts & Humanities Citation Index. The quality and depth of content Web of Science offers to researchers, authors, publishers, and institutions sets it apart from other research databases. The inclusion of News of NAS RK. Series of chemistry and technologies in the Emerging Sources Citation Index demonstrates our dedication to providing the most relevant and influential content of chemical sciences to our community. Қазақстан Республикасы Ұлттық ғылым академиясы "ҚР ҰҒА Хабарлары. Химия жəне технология сериясы" ғылыми журналының Web of Science-тің жаңаланған нұсқасы Emerging Sources Citation Index-те индекстелуге қабылданғанын хабарлайды. Бұл индекстелу барысында Clarivate Analytics компаниясы журналды одан əрі the Science Citation Index Expanded, the Social Sciences Citation Index жəне the Arts & Humanities Citation Index-ке қабылдау мəселесін қарастыруда. Webof Science зерттеушілер, авторлар, баспашылар мен мекемелерге контент тереңдігі мен сапасын ұсынады. ҚР ҰҒА Хабарлары. Химия жəне технология сериясы Emerging Sources Citation Index-ке енуі біздің қоғамдастық үшін ең өзекті жəне беделді химиялық ғылымдар бойынша контентке адалдығымызды білдіреді. НАН РК сообщает, что научный журнал «Известия НАН РК. Серия химии и технологий» был принят для индексирования в Emerging Sources Citation Index, обновленной версии Web of Science. Содержание в этом индексировании находится в стадии рассмотрения компанией Clarivate Analytics для дальнейшего принятия журнала в the Science Citation Index Expanded, the Social Sciences Citation Index и the Arts & Humanities Citation Index. Web of Science предлагает качество и глубину контента для исследователей, авторов, издателей и учреждений. Включение Известия НАН РК в Emerging Sources Citation Index демонстрирует нашу приверженность к наиболее актуальному и влиятельному контенту по химическим наукам для нашего сообщества.

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N-methyl-2-(4-styrylphenyl)-3,4-fulleropyrrolidine synthesis and structureNew stilbene fulleropyrrolidine has been synthesized by С60 fullerene triple-component condensation with sarcosine and trans-4-stilbene carboxaldehyde in Prato reaction conditions. It was demonstrated that primary factor having influence on this reaction final product yield is the homogeneity of the reaction medium. The highest yield of N-methyl-2-(4-styrylphenyl)-3,4-fulleropyrrolidine is observed when reaction performed in xylene and reactive medium is heated. Synthesized compound structure has been studied by IR-, UV-, NMR 1 Н and 13 С spectroscopy as well as by two-dimensional COSY ( 1 H-1 H) and HMQC ( 1 H-13 C) spectra data. The purity and individuality of obtained fulleropyrrolidine have been evaluated using HPLC analysis. N-methyl-2-(4styrylphenyl)-3,4-fulleropyrrolidine synthesis proceeds by the 1,3-dipolar addition to fullerene С60 mechanism through formation of active azomethinilides. N-methyl-2-(4-styrylphenyl)-3,4-fulleropyrrolidine and poly-Nvinylpyrrolidone water-soluble complex has been obtained in dichloromethane. It was shown that complex formation is outcome of fulleropyrrolidine solubilization by PVP chains and lactamic group physical interaction with the fullerene sphere.

Supramolecular inclusion complexes of functionally substituted N-benzylideneand allylidene-isonicotinohydrazides with oligosaccharides and their propertiesThis paper presents the results of a study of the synthesis and structural features of supramolecular inclusion complexes of N-benzylidene-and allylidene-isonicotinohydrazides with cyclic oligosaccharides (with βand 2-hydroxypropyl-β-cyclodextrins). The results of studying the synthesis and structural features of supramolecular inclusion complexes of N-benzylidene and allylideneisonicotinohydrazides with cyclic oligosaccharides (β-and 2-hydroxypropyl-β-cyclodextrins) are presented. The structure of the obtained supramolecular inclusion complexes was studied using one-dimensional 1 H, 13 C and DEPT NMR and two-dimensional spectroscopy of COSY ( 1 H-1 H), HMQC ( 1 H-13 C) and TOCSY ( 1 H-1 H). The formation of supramolecular inclusion complexes was established on the basis of changes in the chemical shifts of the NMR of the substrate and receptor atoms. Based on the analysis of spectral data, the proposed schemes of the obtained supramolecular inclusion complexes are presented. It was found that the interaction of the studied hydrazone substrates with cyclodextrins forms inclusion complexes 1:1 and 1:2 with the entry of the substrate molecule into the internal cavity of the receptor. The resulting products are able to dissolve in water or form stable aqueous dispersions. The antiradical effect of the synthesized supramolecular inclusion complexes with respect to the 2,2-diphenyl-1-picrylhydrazide radical was evaluated. Under the conditions of this test system, antiradical activity was detected in the supramolecular complex of N-(diethylamino)benzylidene-isonicotinohydrazide. The concentration of the complex was determined, capable of reducing the optical density of 100 μM of the test system solution by 50 %.