Doxorubicin containing micro and nanoparticles obtained by layer by layer adsorption of dex tran sulfate and chitosan on an insoluble antibiotic-polyanion complex with subsequent sonication were studied. The effects of the molecular mass of biopolymers, the number of polyelectrolyte layers, and the pH of the reaction medium on the composition, physicochemical properties, and the efficiency of doxorubicin incorporation have been examined. The release of doxorubicin and the mucoadhesive properties of the poly electrolyte particles have been analyzed to determine the possibilities of their potential applications.
This study was aimed at examination of microparticles formed via the layer by layer adsorption of dextran sulfate and chitosan onto the insoluble complexes of various proteins with polyanions. Microparticles with all tested proteins were stable at pH values of 1-5. At pH > 6 the mucoadhesivity of the microparticles changed and the encapsulated proteins were released. Microparticles were able to protect the proteins from proteases. Proteinous protease inhibitors encapsulated as well (2-3%) completely prevented protein proteol ysis. The pharmacological effect of microencapsulated insulin was studied in vivo using the model of chronic diabetes in rats, which were treated by oral administration.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.