The article presents the results of investigation of violations in the proteolysis system in patients with type 2 diabetes and diabetic retinopathy (DR). We studied the levels of matrix
Increasing the levels of MMP-9 and TIMP-1 took place with increasing of DR severity and reached its maximum levels at the proliferative stage of DR. It was found that the levels of MMP-9 in the intraocular fluid and type 2 diabetes duration affected the probability of developing diabetic macular edema. At the level of MMP-9 ≥ 105 ng/ml and 2 diabetes duration ≥ 10 years, the probability of developing macular edema was 100%. As a result of the construction of predictive models it was found that the level of MMP-9 in the intraocular fluid, stage of DR at the beginning of observation and type 2 diabetes duration had influence on the probability of the development of proliferative DR over 4 years of follow-up. If the level of MMP-9≥ 100 ng/ml, type 2 diabetes duration ≥ 10 years and absence of DR at the beginning of observation were observed the probability of developing proliferative DR would compose 85.9%. Key words: proteolysis system; metalloproteinase-9; tissue inhibitor of matrix metalloproteinase-1; intraocular fluid; diabetic retinopathy.
Изучена эффективность фибратов и статинов в профилактике прогрессирования диабетической ретинопатии у больных сахарным диабетом 2 типа. Установлено, что эффективность фибратов в течение 12 месяцев наблюдения была выше, чем статинов (р<0,001).В группе, где применялся фенофибрат, макулярный отек развивался реже, чем в группе, где назначался розувастатин (р=0,023). Назначение фенофибрата позволило, в сравнении с группой применения статина, сохранить толщину сетчатки в фовеа стабильной (р=0,004).
Values of surgically induced astigmatism after phacoemulsification with IOL implantation in patients with cataract were investigated. It was established that after phacoemulsification with IOL implantation the value of surgically induced astigmatism was in the range from 0.04 D to 3.76 D. Surgically induced astigmatism after phacoemulsification with IOL implantation depends not only on the incision size and location. It also depends on anatomical-functional parameters of the eye among which it is possible to distinguish the degree of preoperative corneal astigmatism, corneal rigidity, IOP value as well as patient's age.
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