In order to produce electron beams with the minimum possible energy spread we have investigated the possibility of replacing the usual thermocathodes with a photoemissive source such as GaAs. A comparison carried out between these two sources indicated the latter as the best device to obtain a very-low-energy spread. Beam relaxation after emission also leads to an increase in the energy spread. Therefore an experimental study on the nature of relaxations occurring in electron beams, yielded both by a thermocathode and by a photocathode, has been performed. More specifically, we investigated the possibility of reducing the transverse-longitudinal and the longitudinal-longitudinal relaxations. With this aim, the features of adiabatic acceleration, which damp the pure longitudinal relaxation, have been examined. The experience gained during the measurement cycle demonstrated that an adiabatic structure, accelerating electrons emitted by a GaAs photocathode, leads to the best performances
An experimental investigation was carried out to measure the response time of GaAs in negative electron affinity conditions as a photoemitter. During the experiment, the photocathode was excited by a short-pulse (38 ps rms) frequency-doubled Nd:YLF laser. Results show that the rms response time of GaAs is shorter than 40 ps
Elevated plasma low-density lipoprotein cholesterol (LDL-C) is an important risk factor for cardiovascular diseases. Statins are the most widely used therapy for patients with hyperlipidemia. However, a significant residual cardiovascular risk remains in some patients even after maximally tolerated statin therapy. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a new promising therapeutic target for decreasing LDL-C. PCSK9 reduces LDL intake from circulation by enhancing low-density lipoprotein receptors (LDLR) degradation and preventing LDLR recirculation to the cell surface. In addition to examining the functional role of PCSK9, this review also discusses new drugs for the treatment of hyperlipidemia — PCSK9 inhibitors.
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