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In the present study the assay results of prolactin concentrations in serial samples of blood obtained from premenopausal women with benign or malignant disease of the breast are compared with--and discussed in relation to--findings reported in earlier studies based on single samples of blood taken at various times from a large and ostensibly normal population of women. The finding of an abnormality in nycthemeral prolactin levels in the established disease is considered to strengthen the concept that the same abnormality found in high-risk groups is of aetiological importance.

Beta-thromboglobulin, a platelet-specific protein secreted into the plasma during the release reaction, was measured in 73 women with breast cancer, 10 women with displastic disease and 30 healthy female control subjects. 73% of patients with primary operable breast cancer and 65% with metastatic disease had levels above 40 ng/ml (control range 11–38 ng/ml). Among 2–6 months’ postoperative patients without evidence of disease at the time of sampling, beta-thromboglobulin was raised in 75% of patients with nodal involvement and in 28% of patients without nodal involvement. Only 1 of 10 patients with benign disease showed abnormal beta-thromboglobulin concentration. Our results show that in a high percentage of breast cancer patients a state of ongoing in vivo platelet activation may be present. Furthermore, beta-thromboglobulin can be regarded as a potential tumor marker in breast cancer.

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Die Notwendigkeit einer möglichst genauen Beurteilung der anatomischen sowie der funktionellen Zustände der Semilunarklappen der Aorta hat angesichts der Indikationsstellung zur transventrikulären oder transaortalen Valvulotomie ein großes praktisches Interesse erreicht.Die Möglichkeit einer operativen Behandlung der isolierten oder einer mit einem Mitralvitium kombinierten Aortenstenose, des Aortenvitiums mit überwiegender Stenose und geringer Insuffizienz, sowie die Notwendigkeit, das gleichzeitige Vorhandensein eines Aortenvitiums und eines persistierenden Ductus Botalli oder einer Aortenisthmusstenose festzustellen, haben zu immer mehr verfeinerten und geHeruntergeladen von: University of British Columbia. Urheberrechtlich geschützt.