used to estimate the persistence of treatment overall and comparatively between biologics naïve patients and switchers from other biologics. Results: Threehundred-one (103 RA, 122 AS, 76 PsA) patients were followed for 515 patient-years (median 1.24 (IQR 0.5-2.7) years). The proportions of females in RA/AS/PsA groups were 76%/37%/51%. Median ages at golimumab initiation and times from diagnosis to golimumab treatment in RA/AS/PsA groups were 59/49/44 and 6.8/4.8/8.0 years, respectively. Golimumab was the first biologic in 79%/67%/70% of patients with RA/AS/PsA. Amongst RA patients 73%/74% were RF/ACPA positive and 86% of AS patients HLA-B27 positive. The proportions of RA/PsA patients who were on concomitant conventional DMARDs (glucocorticoids) at baseline were 85% (36%)/72% (8%). At the initiation of golimumab mean PromisHAQ was 40/31/39 in RA/AS/PsA; mean DAS28 5.6/5.0 in RA/PsA; mean BASDAI 5.9 in AS group(s). Among patients with measured disease activity at 6 (12) months 47% (59%)/77% (64%) of RA/PsA patients achieved DAS28< 3.2 and 54% (54%) of AS patients achieved at least 2.0 reduction of BASDAI. The proportions of RA/AS/PsA patients discontinuing golimumab treatment overall were 42%/23%/37%. Reasons for discontinuation were ineffectiveness in 68%/89%/71% in RA/AS/PsA. The unadjusted persistence of golimumab treatment for RA/AS/PsA at 6, 12, 24 months was 97%, 82%, 65%/96%, 91%, 73%/97%, 83%, 57%, respectively and did not differ significantly between biologics-naïve patients and switchers. ConClusions: In Slovenia, the persistence of golimumab after 2 years of treatment was 65%/73%/57% in RA/AS/PsA groups. Switcher status seems not to affect the persistence of golimumab regardless of indication.
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