According to the World Health Organization (WHO), viral diseases form serious public health problem. WHO announced that the disease caused by the new virus named coronavirus disease 2019 or Coronavirus disease 2019 (COVID-19), and the virus causing the infection was named SARS-Cov-2 by the International Committee on Taxonomy of Viruses. Children usually have asymptomatic or mild forms. However, children with comorbidity are in risk of developing severe forms of COVID-19. The review presents modern ideas about the amount of laboratory tests in cases of suspected presence of the SARS-CoV-2 virus, methods of radio diagnostic (computer tomography, x-ray, thorax ultrasound), features of the clinical course of infection in children depending on the severity of the of infection and indicated detailed criteria for severe forms of coronavirus infection. Special attention is focused on the clinical monitoring of children in a non-core hospital: the detection of leukopenia and lymphopenia, CRP level control, monitoring of coagulation disorders, providing tests on other respiratory viruses. Specific recommendations, comprehensive to date, on the use of drugs for the treatment of children with COVID-19 upon admission to a non-core hospital are given. The organisational issues of treatment children infected with COVID-19 in a non-core hospital are described in details. Special attention is focused on the compliance of strict safety rules by staff working with infected patients entering and leaving the Red zone. Thus, the proper organisation of the units for the treatment of children infected with COVID-19 in a non-core hospital, taking into account the features of their disease, will make it possible to provide complete and high-quality treatment of infection during the pandemic.
Introduction: Congenital heart defects are one of the most common malformations. Almost 50 % of patients with congenital heart defects require cardiac surgery. Nosocomial infections strongly influencing the effectiveness of postoperative rehabilitation remain among the major problems of modern health care.
Objective: To establish risk factors for infectious complications in children with congenital heart defects after cardiac surgery.
Materials and methods: In 2014 to 2021, we conducted a case–control study of 603 patients under the age of 18 with congenital heart defects who underwent 643 cardiac surgeries at the perinatal center. The case cohort included 134 children of both sexes
having infectious complications while the control cohort included 469 children of both sexes showing no signs of nosocomial infections after cardiac surgeries. We assessed the role of endogenous and exogenous risk factors for postoperative infectious complications and the relationship between the exposure and the outcome based on the odds ratio. Testing for significance of differences was performed by hypothesis assessment with the calculation of the p-value and estimation of confidence
intervals.
Results: The incidence density of healthcare-associated infections was 15.6 (13.26–18.32) per 1,000 patient-days. The most significant endogenous and exogenous risk factors were identified.
Conclusions: The established predictors of infectious complications indicate the need for a risk-based approach to prevention of nosocomial infections in pediatric cardiac surgery.
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