Canine venereal transmissible tumor (CTVT) is a round cell benign neoplasia that affects the external genital mucous which is transmitted during coitus with infected dogs. The normal canine behaviour such as smelling and sucking allow the tumoral cells to implant into extragenital zones with subsequent metastases formation. This report described a dog with multiple skin nodules localised in the thoracolumbar area and eyes. The nodules were ulcered and alopecic with purulent fluid around them. A granulomatous mass with focal necrosis area was also detected with bilateral keratitis. Citological analysis of skin nodules, eyelid tissue and granulomatous tissue on the base of the penis suggested a CTVT, and the histopathological analysis confirmed the diagnosis of CTVT. Also LINE-1 rearrangement in c-myc was detected as a genetic alteration of the CTVT. A chemotherapy protocol was started with vincristine sulfate. Haemograms were used previous to each chemotherapy sessions to prevent myelosuppression. A moderate non regenerative anemia was observed after the third session but it was resolved by discontinuing chemotherapy for two weeks. The chemotherapy was effective to eliminate the CTVT after six sessions.
In the survey analysis, the missing data problem can be managed by using Multiple Imputation (MI) methods. In this paper we show the empirical application of MI methods to the financial variables included in Chile's Social Protection Survey 2004. Based on a brief review of MI methods we conclude that Multivariate Normal one is more appropiate for our case. In addition, we consider two empirical adjustments: (1) use of the variables in their logistic versions, and (2) implementation of the method by groups of individuals. Our results show that both adjustments improves the performance of the MI method.
En este artículo consideramos una extensión del modelo de Vasicek (1991) para los nuevos créditos de consumo en cuotas otorgados por el sistema bancario chileno. Según el supuesto de que la economía experimentó un ciclo económico completo durante 2003-2009, podemos calcular que la llamada probabilidad de impago en el largo plazo (PILP) es de 14.4%, si se considera el número de créditos en moratoria, o de 12.9% si se pondera la frecuencia de impago por el monto del crédito. Nuestro modelo permite un umbral de incumplimiento variable en el tiempo, que es función tanto de factores macroeconómicos como de características de los deudores. Además, los ejercicios contrafactuales indican que los estándares de las solicitudes de crédito se relajaron durante el periodo 2006-2007, lo cual implica un aumento en la tasa de impago.
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