Tumor venéreo transmisible diseminado sobre piel, párpados y pene en un perro: Reporte de caso

Abstract

Canine venereal transmissible tumor (CTVT) is a round cell benign neoplasia that affects the external genital mucous which is transmitted during coitus with infected dogs. The normal canine behaviour such as smelling and sucking allow the tumoral cells to implant into extragenital zones with subsequent metastases formation. This report described a dog with multiple skin nodules localised in the thoracolumbar area and eyes. The nodules were ulcered and alopecic with purulent fluid around them. A granulomatous mass with focal necrosis area was also detected with bilateral keratitis. Citological analysis of skin nodules, eyelid tissue and granulomatous tissue on the base of the penis suggested a CTVT, and the histopathological analysis confirmed the diagnosis of CTVT. Also LINE-1 rearrangement in c-myc was detected as a genetic alteration of the CTVT. A chemotherapy protocol was started with vincristine sulfate. Haemograms were used previous to each chemotherapy sessions to prevent myelosuppression. A moderate non regenerative anemia was observed after the third session but it was resolved by discontinuing chemotherapy for two weeks. The chemotherapy was effective to eliminate the CTVT after six sessions.

Pulmonary metastasis of transmissible venereal tumour in a dog: a case report

“…It is proposed that the atypical manifestation is associated with a poor host immune response to tumour proliferation. In addition, comorbidities such as mitral valve myxomatous degeneration and glomerulonephritis may have contributed to the spread of the disease (OJEDA et al, 2016;PINCZOWSKI et al, 2015). Additionally, immunosuppression is a fundamental factor for the occurrence of lymphatic and/or blood metastases (OJEDA et al, 2016;RAMOS et al, 2019).…”

“…In addition, comorbidities such as mitral valve myxomatous degeneration and glomerulonephritis may have contributed to the spread of the disease (OJEDA et al, 2016;PINCZOWSKI et al, 2015). Additionally, immunosuppression is a fundamental factor for the occurrence of lymphatic and/or blood metastases (OJEDA et al, 2016;RAMOS et al, 2019). The exclusively extragenital form of firm nodule consistency, where it is not friable or has an exophytic growth is typically described for this tumour.…”

Análisis de 24 casos de Tumor Venéreo Transmisible (TVT) en dos clínicas veterinarias de Florencia, Colombia

“…The location of the tumour is related to the mode of transmission. It is almost always in the genital area, due to transmission through mating, but these lesions can be evidenced in other parts of the body such as the adjacent skin, as well as genital, oral and conjunctival mucosa, caused by transmission during social behaviours such as licking and sniffing (Ganguly et al, 2016;Ojeda et al, 2016).…”

Presence of Papillomavirus DNA sequences in the canine transmissible venereal tumor (CTVT)

“…This neoplasm appears as a tumoral mass at the glans bulb in males, or in the vaginal vestibule in females (Ganguly, Das & Das, 2016), and normally has a high ratio of chemotherapy response (Birhan & Chanie, 2015). The CTVT is found more frequently at the genital area, while less in the oral cavity, nasal cavity, eyes or on the skin (Ganguly, Das & Das, 2016; Ojeda et al, 2016). The CTVT occurrence is worldwide, with the highest incidence in tropical areas.…”