Addition of a recommended dose of phosphorein biofertilizer into salinized soil, induced significant increases in all growth and reproductive parameters determined in growing lettuce plants throughout the entire period of the experiment. On the other hand, fertigation of such sodic salty soil with a recommended dose of nitrobein biofertilizer, induced slight, if any decreases, in growth and reproductive parameters at vegetative, flowering and fruiting growth stages. The contents of carbohydrates fractions as well as the pigment contents and the activity of PS II, of salinized lettuce plants fertigated with phosphorein biofertilizer, were increased throughout the three successive growth stages, above the control levels. On the other hand, with nitrobein biofertilizer slight, if any changes, in all metabolites determined, throughout the entire period of the experiment were obtained. Strong positive and negative correlations were observed between the changes in all growth and reproductive parameters and the changes in all metabolites determined in salinized lettuce plants fertigated with phosphorein and nitrobein, respectively.