Objective. To find the relation between the endometrial sonographic parameters and the success of ICSI in normal responders. Material and Methods.A prospective cohort study was performed from September 2020 to March 2022 including 262 women normal responder women undergoing an ICSI cycle. Endometrial thickness (ET), endometrial pattern, and sub-endometrial blood flow were measured on the day of HCG. According to ET, the patients were classified into 3 groups: < 8 mm, 8-12 mm, and > 12 mm, according to endometrial pattern into a triple and non-triple line, as well as according to endo-sub endometrial blood flow into the zone I, zone II and zone III. Pregnancy rates were compared between all groups.Results. The overall pregnancy rate among all groups was 43.12%. The clinical pregnancy rate was significantly lower with ET below 7 mm; but, increased in the group with ET 8-12 mm 86/113 (76.1%), lower in the group with ET > 12 mm 25/113 (22.1%), and lowest when ET < 8 mm 2/113 (1.8%). The pregnancy rate in the triple endometrial pattern 70/113 M a n u s c r i p t a c c e p t e d f o r p u b l i c a t i o n (61.9%) is higher than in the non-triple pattern 43/113 (38.1%). However, the endo-sub endometrial blood flow did not affect the pregnancy rate significantly (P-value = 0.435). Conclusions.Endometrial thickness exhibits a curvilinear relationship with pregnancy outcomes in fresh embryo transfer cycles. A triple ET 8 mm thickness or more, could be a reliable predictor for successful pregnancy outcomes in fresh ICSI cycles. Yet, ET (≤ 7 mm) and no triple-line endometrial pattern coexist in an ICSI candidate, cryopreservation should be recommended.
Objective. Correlating Human Papillomavirus (HPV) serotyping, the findings of PAP-smear, colposcopy with colposcopic directed biopsy. Sharing our epidemiological data guides the local health authorities to formalize national screening protocols. Patient and Methods.A retrospective study was conducted at the Gynecological clinic of a tertiary University Hospital during the period between 2015 to 2020. A total of 285 women's medical records were reviewed for epidemiological, clinical presentation and Pap smear, HPV serotypes, colposcopy findings, and colposcopic guided biopsy. The results were plotted and correlated based on histopathological results.Results. HPV substantial risk types were detected in 74 (25.8%), and minimal risk serotypes were detected in 28(9.7%). 16 positivity was evident in 13 (12.03%) patients, followed by HPV 31 serotype in 12(11.1%), HPV-51 detected in 11 (10.8%), HPV 18 positivity in 10 (10.02%), while HPV negative in 128 (44.7%). The sensitivity of colposcopy was higher than Pap smear (93.2% Vs 68.52%); however, its specificity was only 69.1% compared to 96.7% of the Pap smear. Our results demonstrated a high agreement between colposcopy and histology 95.36%. similarly, Pap smear and colposcopy agreement was high up to 98 %, but between Pap smear and histology was 84%. Conclusions.Pairing the result of HPV serotypes with the grade of abnormal cytology, colposcopic appearance, and histopathological findings could improve the early detection of preinvasive lesions.
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