The relation between human papilloma virus serotype infection and colposcopic, cytological and histopathological abnormalities among the Egyptian women: retrospective study

Abstract

Objective. Correlating Human Papillomavirus (HPV) serotyping, the findings of PAP-smear, colposcopy with colposcopic directed biopsy. Sharing our epidemiological data guides the local health authorities to formalize national screening protocols. Patient and Methods.A retrospective study was conducted at the Gynecological clinic of a tertiary University Hospital during the period between 2015 to 2020. A total of 285 women's medical records were reviewed for epidemiological, clinical presentation and Pap smear, HPV serotypes, colposcopy findings, and colposcopic guided biopsy. The results were plotted and correlated based on histopathological results.Results. HPV substantial risk types were detected in 74 (25.8%), and minimal risk serotypes were detected in 28(9.7%). 16 positivity was evident in 13 (12.03%) patients, followed by HPV 31 serotype in 12(11.1%), HPV-51 detected in 11 (10.8%), HPV 18 positivity in 10 (10.02%), while HPV negative in 128 (44.7%). The sensitivity of colposcopy was higher than Pap smear (93.2% Vs 68.52%); however, its specificity was only 69.1% compared to 96.7% of the Pap smear. Our results demonstrated a high agreement between colposcopy and histology 95.36%. similarly, Pap smear and colposcopy agreement was high up to 98 %, but between Pap smear and histology was 84%. Conclusions.Pairing the result of HPV serotypes with the grade of abnormal cytology, colposcopic appearance, and histopathological findings could improve the early detection of preinvasive lesions.

relationship between HPV positivity and abnormal cervical cytology changes with age in perimenopausal women

“…Although classification according to age at 30 years is definitely warranted when employing HPV DNA testing in screening, it is unclear if the suggestions for females above thirties are similarly true during the life span of a woman of screening. "Because the rate of pre-neoplastic disease is low (8), few studies of women over age 30 have the power to further stratify by age in order to better inform guidelines" (7)(8)(9)(10)(11) Women with all grades of "pathology-confirmed cervical intraepithelial neoplastic (CIN)" showed a reduction in HR-HPV identification with age, with the most pronounced decline seen for HPV 16 infection, according to a recent study from the ATHENA trial, that contained data on more than thirty five thousand women aged thirty and older. "In the HPV in Perimenopause (HIP) cohort of routinely screened women age 35-60 years, we observed a similar trend of decreasing correlation between HR-HPV detection and cervical abnormalities with increasing age" Our goal was to learn more about the relationship between agerelated aberrant cytology and either HPV and HR-HPV detection (12)(13)(14).…”