INTRODUCTION: Platypnea-orthodeoxia syndrome (POS) is a rare condition that is characterized by both dyspnea (platypnea) and arterial desaturation (orthodeoxia) in the upright position which resolves with recumbency. This syndrome can be categorized by etiology, which includes intracardiac shunting, pulmonary shunting, ventilation-perfusion mismatch, and disorders such as pericarditis, emphysema, and pneumonectomy.
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