The DIscriminant‐REgression Model (DIREM) belongs to the ordinary discrete‐continuous QSAR approach, and has been proposed to explore SAR's for compounds with the same type of activity but different features of biological action. As a function scaling method, DIREM reveals the correspondence between structure descriptions and the distribution of compounds on a scale of biological activity. Model building is an iterative process that includes cluster formation using a stepwise procedure of linear discriminant analysis (LDA), and the discovery of quantitative relationships within each cluster by means of stepwise multiple regression analysis (MRA). DIREM is available in the software packages CLARAS (CLAssification and Recognition of Active Structure) and DNESTR (Design of New Effective STRuctures). Examples of DIREM application (guppy toxicity of aliphatic compounds, and β‐adrenergic activities of phenethylamines) are discussed.
Recently, several applications have required radio frequency filters with a narrow bandwidth and high attenuations. A ZnO film/quartz structure has a good potential to such a requirement. In this paper, we show the optimization of the ZnO/quartz structure to obtain a nearly zero temperature coefficient of frequency (TCF) while maximizing the electro-mechanical coupling coefficient (k 2 ). In the previous papers published by one of the authors about the ZnO/quartz structure, a nearly zero TCF with a small electro-mechanical coupling coefficient, or non-zero TCF with maximized k 2 was reported. However, both zero TCF and maximized k 2 have not yet been simultaneously obtained. In this study, we investigated the optimized structure by calculation and also confirmed it by measurement. #
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