Postganglionic sympathetic nerve activity (renal nerve) decreased significantly during i.v. infusion of a beta-adrenergic blocking drug, atenolol, in anesthetized rabbits. This phenomenon, at least in part reflex in nature, may contribute to the hypotensive effect of atenolol.
Baroreceptor activity was increased after i.v. infusion of acebutolol in rabbits with an intact circulation, and in rabbits with a total cardiopulmonary by-pass. In rabbits with an intact circulation, renal nerve activity was reduced.
1. -- Aortic nerve activity was simultaneously measured in anaesthetized rabbits by spike-frequency counting and integrative methods during decreases by bleeding in mean blood pressure (MBP) from 130 to 50 mm Hg. Values of counted and integrated activities were expressed in arbitrary units. 2. -- No statistically significant difference between the counted and integrated activity was pointed out in the range of MBP from 130 to 90 mm Hg. 3. -- Below a MBP of 90 mm Hg, the counted activity was significantly higher than the integrated activity. This difference could be the result of a better appraisal of the number of small and medium spikes by the counting equipment than by the integrating system.
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