Post extra-systolic potentiation during coupled stimulation of the heart

Chevalier-Cholat, A M; Torresani, J; Saadjian, A; Heuillet, G; Jouve, A

doi:10.1016/s0022-0736(71)80019-5

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…The therapeutic use of PESP has been extensively investigated in the 1960s and 1970s, but has long been abandoned due to conflicting evidence of its effectiveness. [59][60][61][62] Inducing PESP, and therefore increasing the force of contraction, might be beneficial in heart failure patients. By using coupled or paired pacing, in which a premature beat is introduced after every other intrinsic or paced beat, respectively, the effect of PESP is extended, which improves contractility and cardiac output.…”

Section: Therapeuticsmentioning

confidence: 99%

Post-extrasystolic Potentiation: Link between Ca2+ Homeostasis and Heart Failure?

Sprenkeler

Vos

2016

Arrhythmia &Amp; Electrophysiology Review

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Post-extrasystolic potentiation (PESP) describes the phenomenon of increased contractility of the beat following an extrasystole and has been attributed to changes in Ca(2+) homeostasis. While this effect has long been regarded to be a normal physiological phenomenon, a number of reports describe an enhanced potentiation of the post-extrasystolic beat in heart failure patients. The exact mechanism of this increased PESP is unknown, but disruption of normal Ca(2+) handling in heart failure may be the underlying cause. The use of PESP as a prognostic marker or therapeutic intervention have recently regained new attention, however, the value of the application of PESP in the clinic is still under debate. In this review, the mechanism of PESP with regard to Ca(2+) in the normal and failing heart will be discussed and the possible diagnostic and therapeutic role of this phenomenon will be explored.

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Section: Therapeuticsmentioning

confidence: 99%

Post-extrasystolic Potentiation: Link between Ca2+ Homeostasis and Heart Failure?

Sprenkeler

Vos

2016

Arrhythmia &Amp; Electrophysiology Review

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Effect of paired ventricular pacing upon myocardial infarction size

Karayannacos

Boudoulas

Pasley

et al. 1977

Journal of Surgical Research

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2-APB Induces Instability in Rat Left Atrial Mechanical Activity

Wolkowicz

Wu²,

Urthaler³

et al. 2007

Journal of Cardiovascular Pharmacology

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Atrial contractile abnormalities are common clinical disorders but few pharmacological models can reliably produce such abnormalities in isolated atrial muscle. Since sarcoplasmic reticulum (SR) calcium leak may underlie these contractile irregularities, we investigated whether 2-aminoethoxydiphenyl borate (2-APB), a calcium leak-inducer, affects mechanical function in isolated, superfused rat left atria. Exposing left atria paced at 3 Hz to >10 microM 2-APB produced sporadic mechanical events that occurred in the absence of pacing stimulus. Prolonging atrial diastole in the presence of 2-APB produced spontaneous mechanical activity (SMA) defined as numerous mechanical events occurring in the absence of pacing stimulus. SMA depends on atrial sodium and chloride gradients as decreasing superfusate concentration of either ion suppressed SMA. Increasing superfusate potassium to produce an EK of approximately -74mV reversed SMA, revealing possible membrane potential sensitivity. Mechanical function decreased with time in left atria treated with 2-APB and low sodium or the anion transport inhibitor 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) compared with atria exposed to low sodium or DIDS alone, suggesting 2-APB may decrease left atrial SR activator calcium. Thus, 2-APB produces instability in regular left atrial mechanical activity that may require forward-mode sodium-calcium exchange and chloride channel activities. This data identify a new model for studying atrial contractile abnormalities.

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Post extra-systolic potentiation during coupled stimulation of the heart

Cited by 3 publications

References 14 publications

Post-extrasystolic Potentiation: Link between Ca2+ Homeostasis and Heart Failure?

Post-extrasystolic Potentiation: Link between Ca2+ Homeostasis and Heart Failure?

Effect of paired ventricular pacing upon myocardial infarction size

2-APB Induces Instability in Rat Left Atrial Mechanical Activity

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