A total of 78 cases of laboratory acquired infections occurred at D. I. Ivanovsky Institute of Virology, M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitis and Rostov na Donu Institute of Epidemiology, Microbiology and Hygiene. All these cases were caused by accidental infection of the staff with the following viruses: Venezuelan equine encephalomyelitis (n=34), Kyasanur forest disease (n=1), Omsk hemorrhagic fever (n=1), CrimeanCongo hemorrhagic fever (CCHF) (n=2), Dhori (n=5), vesicular stomatitis (n=1), Machupo (n=3), and hemorrhagic fever with the renal syndrome (n=31). The majority of cases were caused by inhaling virus aerosols. All cases were a result of accidents or neglect of safety measures. Diagnoses were confirmed by virus isolation and/or detection of specific antibodies in convalescent serum. With the exception of one lethal case of CCHF, patients recovered without disability. The pathogenicity of Dhori virus in man was discovered as a result of laboratory infection of 5 staff members.
A genome of bank vole virus (BaVV), isolated from kidney tissues of bank voles (Myodes glareolus) in Russia in 1973, was sequenced. The genomic organization of BaVV (3'-N-P/V/C-M-F-G-L-5', 16,992 nt in length; GenBank accession number MF943130) is most similar to that of Mossman virus (MoV) and Nariva virus (NarPV), two ungrouped paramyxoviruses isolated from rodents in Australia and Trinidad, respectively. The proteins of BaVV have the highest level of sequence identity (ranging from 23-28% for G protein to 66-73% for M protein) to proteins of MoV and NarPV. The results of genetic and phylogenetic analysis suggest that BaVV represents a new species and, together with MoV and NarPV, belongs to a new, yet not established genus of the family Paramyxoviridae.
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