The application of system theory (or more precisely, differential equations) to immunology and disease, in general, is presented here. Particular results from U.S.-Russian research collaboration depict the potential role of such systematic analysis for more effective health care and disease control. In particular, some emphasis is given to control of influenza. After a brief systematic overview of immunology, a simple infectious disease model is developed to explain four basic forms of disease: subclinical, acute, lethal and chronic. Then, disease treatment is studied.
This paper presents a problem of parametrization in mathematical models of immuno physiologicai processes. The assumption of similarity allows the model parameters for a given body to be recalculated in terms of known parameters for the so-called basal organism or the "average* for a group of patients. The formal approach to the parametrization problem and the method of estimating the parameters for a given organism are discussed. Problems of this type stem from the biological and medical demands.Brought to you by | University of Arizona Authenticated Download Date | 7/13/15 9:21 AM
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