The article presents the results of investigation of antitumor properties of platinum-arabinogalactan complex. We showed the ability of the complex to inhibit the growth of Ehrlich ascites tumor cells. It is found that the distribution of the platinum-arabinogalactan complex is not specific only for tumor cells in mice. The complex was found in all tissues and organs examined (ascites cells, embryonic cells, kidney, and liver). The mechanism of action of the arabinogalactan-platinum complex may be similar to cisplatin as the complex is able to accumulate in tumor cells.
The title compound, trans‐[PtCl4(iso‐NH2C3H7)2], was obtained by oxidation of trans‐[PtCl2(iso‐NH2C3H7)2] with chlorine gas. The crystal structure contains discrete centrosymmetric mononuclear complex molecules, with PtIV in a slightly distorted octahedral coordination environment. The slight distortion, as described by the angles at the PtIV atom, is due, in part, to intramolecular N—H...Cl hydrogen bonding [N...Cl = 2.897 (12) Å]. The Pt—N and Pt—Cl bond lengths are comparable to those in related structures. In the crystal structure, molecules are arranged in layers in the bc plane, with a shortest Pt...Pt distance of 6.1105 (1) Å. The molecules are organized so that isopropylamine ligands project from the layers, forming organic interlayers.
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