Antitumor effect of arabinogalactan and platinum complex

Starkov, A. K.; Zamay, Tatiana N.; Савченко, А. А.; Ingevatkin, E. V.; Титова, Н. М.; Kolovskaya, Olga S.; Luzan, Natalia; Силкин, П. П.; Kuznetsova, S. A.

doi:10.1134/s1607672916020046

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…it is primarily used in the treatment of ovarian, prostate, testicular, lung and gastric cancer (3,4). cisplatin is associated with dose-dependent side effects (5,6), including gastrointestinal reactions (7), bone marrow suppression (8), liver and kidney damage (9), ototoxicity (10) and neurotoxicity (11). renal toxicity is frequently encountered, with a clinical incidence rate of 25-35% (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Differential expression profile analysis of cisplatin‑regulated miRNAs in a human gastric cancer cell line

et al. 2019

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cisplatin, one of the most commonly used drugs in combination chemotherapy, is an effective anti-tumor agent widely used for diverse tumor types. Micrornas (mirnas/mirs) are involved in the occurrence, development, diagnosis and treatment of cancer. Therefore, the aim of the current study was to explore whether cisplatin exerts anticancer effects by causing differential expression of mirnas in human gastric cancer cells. The human gastric cancer cell line nci-n87 was cultured with a certain dose of cisplatin and high-throughput sequencing combined with reverse transcription-quantitative polymerase chain reaction (rT-qPcr) was performed to detect cisplatin-regulated mirnas. mirnas upregulated and downregulated following cisplatin exposure were analyzed. High-throughput sequencing revealed 33 upregulated and 16 downregulated miRNAs. A total of five significantly upregulated and five significantly downregulated mirnas were identified by rT-qPcr. The expression levels of hsa-mir-1246 and hsa-mir-892b were consistent with the results obtained from high-throughput sequencing. Gene ontology and Kyoto encyclopedia of Genes and Genomes pathway clustering of cisplatin-regulated mirnas revealed that the mirnas regulated genes involved in several biological processes and signaling pathways. The results obtained in the current study suggested that cisplatin may exert an important anticancer effect in gastric cancer via complex biological processes and signaling pathways.

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Section: Introductionmentioning

confidence: 99%

Differential expression profile analysis of cisplatin‑regulated miRNAs in a human gastric cancer cell line

et al. 2019

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“…These compounds could be used as sensor, solar cell, fluorescent probe, conducting polymer, etc. On the other hand, the Schiff base ligands and its complexes have showed a broad range of biological activities such as antibacterial, antitumor, antifungal, catechol oxidase, anti‐HIV, DNA cleavage systems, and anti‐inflammatory . Thus, the design and synthesis of novel Schiff base complexes can be useful for wide range of chemical researches.…”

Section: Introductionmentioning

confidence: 99%

Some new 4-coordinated nanostructure cadmium imidazolidine Schiff base complexes: Thermal behavior, antimicrobial, and DNA cleavage potential

2017

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In this study, a new series of cadmium halide/pseudohalide complexes with a novel Schiff base ligand containing imidazolidine ring has been successfully synthesized.The structure of the ligand and its complexes was characterized by analysis tools such as Fourier transform infrared, UV-visible, proton and carbon nuclear magnetic resonance spectra, molar conductance, and thermal analysis. Also cadmium bromide and iodide nanostructure complexes have been prepared via sonochemical method. X-ray powder diffraction and scanning electron microscopy techniques confirmed nanostructure sheets for these 2 cadmium complexes. All the newly prepared compounds were screened for their antimicrobial activities, against 4 bacterial and 2 fungal strains using disk diffusion and serial dilution methods. The CdL(N 3 ) 2 and CdLCl 2 complexes showed the best antimicrobial activity as compared with other compounds. Moreover, DNA cleavage potential of all compounds was investigated by agarose gel electrophoresis method. The results showed remarkable ability of some cadmium complexes for DNA cleavage. Furthermore, thermal behaviors of all cadmium complexes were studied in the range of room temperature to 800°C under nitrogen atmosphere. The complexes were thermally decomposed via 2 to 4 steps. Cadmium metal was suggested as final residue at the end of thermal decomposition process.

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Nucleic Acid Aptamers Increase the Anticancer Efficiency and Reduce the Toxicity of Cisplatin-Arabinogalactan Conjugates In Vivo

Zamay

Starkov

Kolovskaya

et al. 2022

Nucleic Acid Therapeutics

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Antitumor effect of arabinogalactan and platinum complex

Cited by 3 publications

References 4 publications

Differential expression profile analysis of cisplatin‑regulated miRNAs in a human gastric cancer cell line

Differential expression profile analysis of cisplatin‑regulated miRNAs in a human gastric cancer cell line

Some new 4-coordinated nanostructure cadmium imidazolidine Schiff base complexes: Thermal behavior, antimicrobial, and DNA cleavage potential

Nucleic Acid Aptamers Increase the Anticancer Efficiency and Reduce the Toxicity of Cisplatin-Arabinogalactan Conjugates In Vivo

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