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The application of hydroxytriazenes as analytical reagents has been reviewed after 1997 , i.e. from 1998. The literature on the recent work done on hydroxytriazenes has been reviewed and it is found that, apart from being useful analytical reagents for spectrophotometric and complexometric determination of transition metal ions, they have also found application as bioactive compounds. The details of λ," 3Χ or working wavelength with pH conditions etc. have been given in this review. Ressalan et al. 121 have reported the use of 3-hydroxy-3-m-tolyl-l-mnitrophenyltriazene as a metallochromic indicator for the complexometric determination of trace amounts of chromium (III). Using this reagent as an indicator the selective complexometric determination of Cr (III) in binary and ternary metal ion mixtures has also been done. The end point of the titration is marked by change of colour from violet to yellow at a pH between 5.2 to 6.0 using hexamine. It is reported that the presence of 20 fold excess of eleven diverse cations and anions did not interfere with the determination of 5.2 mg of Cr (III). It has been further reported that the amount of metal ions found was in good agreement with the amount of metal ions actually present, indicating that the determinations are quite accurate. For the sake of comparison parallel titrations have been carried out using xylenol orange as indicator. Thus a useful method for the complexometric determination of chromium (III) has been developed. Ressalan et al. 13/ have reported the use of 3-hydroxy-3-p-tolyl-l-onitrophenyltriazene at 60-65°C in hexamine buffer (pH 5.2 to 6.0). The colour reaction results in the formation of a stable dark grassy green chromium complex. The chromium (III): reagent ratio in this complex is 1:2

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The present study is aimed to investigate the anti-inflammatory, antioxidant and antidiabetic activities of three series of hydroxytriazenes based on sulfa drugs viz; Sulphathiazole (ST), Sulfisoxazole (SF) and Sulphamethoxazole (SM). Antidiabetic activities of the synthesized hydroxytriazenes were investigated by α-glucosidase and α-amylase inhibition method and IC 50 values were recorded. The compounds presented significant α-glucosidase and α-amylase inhibition effect with IC 50 values ranging from 122 to 341 μg/mL. Anti-inflammatory activity was also investigated by carrageenan-induced paw edema (CPE) method, where % inhibition was up to 89% after 4 h of treatment and antioxidant properties of the similar compounds were assessed by DPPH and ABTS radical scavenging assays. Antioxidant capacity of all the hydroxytriazenes detected by ABTS assay, was significantly higher as compared to DPPH assay. The hydroxytriazenes having highest antioxidant capacity presented IC 50 values for compound ST-1 and ST-6 are 488 μg/mL for DPPH, 54.12 μg/mL for ABTS and 858.5 μg/mL for DPPH, 48.0 μg/mL for ABTS, respectively. These results suggested that ABTS assay may be more useful than DPPH assay for synthetic antioxidants. The findings from the molecular docking experiments may also expand the formation of new potent sulpha drugs based hydroxytriazenes targeting towards the subunit of C-terminal of human maltaseglucoamylase for the treatment of diabetes metabolic disorder. Overall, highlight the multifunctional role of hydroxytriazenes as antidiabetic, antioxidant and anti-inflammatory agents.