Background:Fluorosis is one of the common but major emerging areas of research in the tropics. It is considered endemic in 17 states of India. However, the Cuddalore district of Tamil Nadu is categorised as a fluorosis non-endemic area. But clinical cases of dental fluorosis were reported in the field practice area of Department of Community Medicine, Rajah Muthiah Medical College, Annamalai University, Chidambaram. Since dental fluorosis has been described as a biomarker of exposure to fluoride, we assessed the prevalence and severity of dental fluorosis among primary school children in the service area.Materials and Methods:Children studying in six primary schools of six villages in the field practice area of Rural Health Centre of Faculty of Medicine, Annamalai University, Chidambaram, were surveyed. Every child was clinically examined at the school by calibrated examiners with Dean's fluorosis index recommended by WHO (1997). Chi-square test, Chi-square trend test and Spearman's rank correlation coefficient test were used for statistical analysis.Results:Five hundred and twenty-five 5- to 12-year-old school children (255 boys and 270 girls) were surveyed. The overall dental fluorosis prevalence was found to be 31.4% in our study sample. Dental fluorosis increased with age P < 0.001, whereas gender difference was not statistically significant. Aesthetically objectionable dental fluorosis was found in 2.1% of the sample. Villages Senjicherry, Keezhaperambai and Kanagarapattu revealed a community fluorosis index (CFI) score of 0.43, 0.54 and 0.54 with 5.6%, 4.8% and 1.4% of objectionable dental fluorosis, respectively. Correlation between water fluoride content and CFI values in four villages was noted to be positively significant.Conclusion:Three out of six villages studied were in ‘borderline’ public health significance (CFI score 0.4-0.6). A well-designed epidemiological investigation can be undertaken to evaluate the risk factors associated with the condition in the study region.

BackgroundSpastic cerebral palsy (CP) is the most common type of CP. Hip adductor spasticity leads to discomfort, stiffness, and difficulties in doing physical activities such as sitting, transfer, and walking. Management of hip adductor spasticity is still a challenge in the field of rehabilitation. Horse riding simulator (HRS) has been reported to have beneficial effects on spasticity, postural control, and motor function in children with spastic CP.ObjectiveThe aim of the study was to determine the immediate effect of HRS on adductor spasticity in children with CP.MethodsTwenty‐four children with CP were selected and were divided into two groups: experimental and control (12 children in each group). Experimental group was exposed to HRS and control group to the corner seat placement. Adductor tone and passive hip abduction range of motion were measured before and after the intervention.ResultsPost intervention scores in the group of HRS show significant reduction in adductor spasticity and improvement in hip abduction range of motion, whereas no difference have been reported in the control group. HRS has positive effects on reducing spasticity and improving range of motion in hip joint in spastic CP.ConclusionIt was concluded that immediate effect of HRS is successful in reducing the adductor spasticity and improving abduction range of motion in hip, which could be incorporated with regular physiotherapy intervention.

Background: Gestational diabetes mellitus (GDM) is a growing epidemiological problem. GDM is defined as the glucose intolerance during pregnancy. Treatment of GDM is important to avoid maternal and fetal complications. The objectives of this study was to assess the knowledge about GDM among antenatal mothers and to find out the association between knowledge and demographic factors.Methods: A descriptive cross sectional study was done among 191 antenatal mothers in Maternity Health Centre and Government Hospital, Chidambaram during September 2017. A pre tested questionnaire was used to assess knowledge about GDM among all antenatal mothers attending OP.Results: Among the participants, 49.2% were in the age group of 21–25 years, 93.7% of them were housewives, 56.0% of them have studied up to higher secondary level and 72.8% of them were living in rural areas. In this study it was found that 35.2% of the participants had adequate knowledge about GDM and 21.5% had adequate knowledge about its risk factors. Education and residence were found to be associated with knowledge and risk factors of GDM which is statistically significant (p<0.05).Conclusions: The knowledge of antenatal women on GDM was just average. There is a need for training the physicians, paramedical people, and public regarding GDM. Health education programs must be conducted to improve the awareness among antenatal women for better utilization of health services. A regular screening of GDM among all pregnant women should be promoted in all health centres.

Recently, free radical—induced tissue damage is implicated in the nonsteroidal anti-inflammatory drugs (NSAIDs)—involved gastric mucosal lesion. Administration of taurine, an endogenous antioxidant, is reported to be beneficial in various clinical conditions. Therefore, we decided to study the protective effect of taurine in ibuprofen-induced gastropathy and the effects of administration of taurine on the endogenous antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX), and reduced glutathione (GSH) of stomach. In rats, administration of taurine orally for three consecutive days (250 mg/kg body weight) protected the gastric mucosa from ibuprofen-induced, acute gastric mucosal lesion. In ibuprofen-treated rats, the lipid peroxidation measured as thiobarbituric acid reactive substances (TBARS), a marker for free radical—induced tissue damage, is also significantly decreased by taurine. Ibuprofen treatment resulted in a significant increase in the activities of total SOD, manganese SOD (Mn-SOD), and GPX and reduced GSH. Taurine administration in ibuprofen-treated rats also showed a significant increase in the activities of the antioxidant enzymes namely total SOD, Mn-SOD, GPX, CAT, and the level of reduced GSH. The activity of copper-zinc SOD enzyme (Cu-Zn SOD) is not affected by ibuprofen or taurine. There is no temporal relation between the antioxidant status of the stomach and the tissue damage following oral administration of ibuprofen or taurine.

The present study evaluates the effects of oral administration of taurine on haematological parameters in normal wistar rats. Tissue oxidative stress is implicated in pathogenesis of various clinical disorders and antioxidant taurine is emerging as prophylactic and therapeutic agent. However, studies on effects of taurine on normal physiology are not reported in literature. Normal saline (Group I) or 5% taurine in normal saline was administered in dose of 50 mg (Group II), 250 mg (Group III) or 500 mg kg(-1) of b.wt. (Group IV) through intragastric intubation for 60 days. The blood cell counts, haemoglobin content, packed cell volume, blood indices, bleeding time and clotting time were estimated using routine laboratory haematological techniques. Neutrophil's phagocytic activity was determined by nitroblue tetrazolium reduction test; serum lysozyme activity was estimated colorimetrically by the degree to lyse bacterial cell suspension and serum taurine levels were estimated by HPLC fluorimetric technique. Platelet count showed a decrease in Group III and IV when compared with Group I and II (p<0.001). Mean corpuscular haemoglobin of Group III and IV are significantly lowered when compared to Group I (p<0.001). A statistically significant decrease was observed in the mean corpuscular haemoglobin concentration between Group 1 and Group IV (p<0.001). The neutrophil percentage of Group II, Group III and Group IV showed a significant increase over Group I (p<0.001). The percentage of lymphocytes showed a significant decrease in Group II, III and Group IV when compared to Group I (p<0.001). Neutrophil's phagocytic activity is significantly lowered in Group III and IV when compared to Group I (p<0.001). The serum lysozyme activity of Group III and IV showed a significant increase over Group I (at p<0.001). From the present study it may be concluded that long term oral administration of taurine affects normal haematological functions.

Background: Delay in seeking health care is one of the key factors leading to maternal death, which can be associated with lack of awareness about obstetric danger signs. So, it is essential that pregnant women should be aware about danger signs of obstetric complications so that they can seek timely healthcare. This study aims to assess level of awareness about danger signs of pregnancy among ANC attendant pregnant women and to assess the factors associated with it.Methods: A descriptive cross-sectional study was done among 170 pregnant women. The level of awareness about danger signs were assessed by administering pre tested proforma to the participants. The collected data was entered in Microsoft excel 2010 and the data was compiled analysed usingSPSS version 21.Results: Of the total participants, only 29.3% had good awareness and about 69.3% had fair awareness about danger signs of pregnancy. It was found that increasing maternal age had significant association with awareness about danger signs whereas other factors like type of family, education, residence, order and duration of pregnancy, number of an visits, previous risk pregnancies had no significant association with level of awareness about danger signs.Conclusions: Level of awareness about danger signs among pregnant women was average. Thus, provision of health education, empowering women and improving the quality of health services can be the recommended interventions.

Background: The use of plastics made life easy in day to day life. However, the disposal of it remains a public health problem worldwide. Plastic waste are major cause of environment pollution becomes carcinogenic to human, birth defects, impaired immunity, endocrine disruption, development and reproductive effect. Raising the awareness of the different stake holders is suggested by United Nations Environment Programme. Assessing the knowledge and practice of the student community, especially of the professional courses, in this regard is considered as a vital one.Methods: A total of 563 students of professional courses were included in the study. Their knowledge in terms general aspects, ill effects, reuse and practice in terms of usage and disposal were assessed with a questionnaire.Results: 46% of the students found having good knowledge. Only 27.6% were found to have good practice. Though the students have good knowledge on ill effects of plastics, their practice in terms of disposal was less. Significant variations were observed among the students of different courses.Conclusions: Addressing the gap between knowledge and practice in terms of designing messages for proper disposal and avoiding usage of single use plastics at individual and collective level is required.

No abstract