Anticardiolipin antibodies (ACA) and lupus-like anticoagulant (LLAC) have been studied in a group of 142 non-hospitalized and a group of 72 hospitalized HIV infected patients. We observed a variable frequency of ACA positivity ranging from 7.7% to 30.3% according to the groups of patients and the isotype of immunoglobulin fraction containing ACA activity. None of the patients investigated presented a prolongation of the activated partial thromboplastin time (APTT) compatible with the presence of a LLAC. Some patients presented a weak anticoagulant activity only detected by the tissue thromboplastin inhibition (TTI) test. No positive correlation was found between this latter test and ACA. We conclude that, like in syphilitic patients, ACA present in HIV infected patients are most often not associated with LLAC.
We studied the concentrations of total and individual gluco-saminoglycans (GAG) extracted from different vessel walls, and their anticoagulant effects on APTT and thrombin time (TT of normal plasma. The vessels considered were varicose veins, veins presumably normal (autologus saphene crosses, various veins taken during autopsy), and aortas (autopsy).The results (mean, sd) are presented in the Table.No important differences were observed between normal veins from different localization, even in veins presenting higher risk of thrombosis like the veins of the lower limits.It is concluded that there is a marked difference in the composition and anticoagulant properties of aortic GAG as compared with venous GAG. Varicose veins showed higher GAG content and stronger anticoagulant properties as compared with normal veins. This latter observation may be a reflect of defense mechanism against thrombotic stress of the higher pressure present in these abnormal veins.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.