We studied the concentrations of total and individual gluco-saminoglycans (GAG) extracted from different vessel walls, and their anticoagulant effects on APTT and thrombin time (TT of normal plasma. The vessels considered were varicose veins, veins presumably normal (autologus saphene crosses, various veins taken during autopsy), and aortas (autopsy).The results (mean, sd) are presented in the Table.No important differences were observed between normal veins from different localization, even in veins presenting higher risk of thrombosis like the veins of the lower limits.It is concluded that there is a marked difference in the composition and anticoagulant properties of aortic GAG as compared with venous GAG. Varicose veins showed higher GAG content and stronger anticoagulant properties as compared with normal veins. This latter observation may be a reflect of defense mechanism against thrombotic stress of the higher pressure present in these abnormal veins.
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