The present work was carried out to study the impact of date palm pits as antibacterial activities on two species of pathogenic bacteria (klebsiella pneumonia and Escherichia coli) and its role in reducing side effect of methylprednisolone on the some neurotransmitter content in the brain, hormone testosterone and testclture of male albino rats .Date palm pits is most effective in inhibiting growth of bacteria as compared with antibiotics due to differences in resistance of bacteria to anti-tested materials due to change in membrane permeability of cells, thereby hindering the entry of enzymes or excreted by the change in the chemical composition of the constituent chemical. The results showed that the daily oral administration of pits of date palm caused the maximal increase in NE, DA& GABA content was found in the brain stem after 2 weeks. The daily oral administration of methylprednisolone caused decrease in NE,DA& GABA content was found in the brain stem after 2 weeks. Moreover, the daily oral administration of pits of date palm and methylprednisolone caused increase in NE content was found in the brain stem after 2 weeks. The daily oral administration of pits of date palm and methylprednisolone caused a significant increase in testosterone level in serum blood of male albino rat. From the present results, it is clear that Effect of chronic oral administration of methylprednisolone and pits of data palm on testicular of male albino rat caused recovery effect, notice high sperm in some tubules and tubular partial late spermatogenic arrest (spermatide level) is only seen in 10-20% of tubules. The appropriate recommendations in this study to use nuclei dates Antimicrobial on klebsiella pneumonia and Escherichia coli than the activity of standard antibiotics and the results concluded that using intended dates date palm pits as a preventive measure to reduce the side effects resulting from the use of a drug methylprednisolone on the some neurotransmitter content in the Brain. Hormone Testosterone and testclture in male albino rats.

Olive oil is an important source of mono-unsaturated fat and a prime component of the Mediterranean diet. The beneficial health effects of olive oil are due to both its high content of mono-unsaturated fatty acids and its high content of anti-oxidative substances. The objective of this study was to investigate the basis for the epidemiological information relating to the health benefits associated with the consumption of ex-tra-virgin olive oil (EVOO). The effect of olive oil on norepinephrine (NE), dopamine (DA), serotonin (5-HT) and gamm-aminobutyric acid (GABA) con-tents in different brain regions and histological structure of liver and kindey of male albino rats was studied. The chronic administration of olive oil (7.5 mg/kg body wt.) caused a significant increase in norepinephrine (NE), dopamine (DA) , serotonin (5-HT) and gamm-aminobutyric acid (GABA) con-tent in different brain regions (Cerebellum, striatum, cerebral cortex, hypothalamus, brain steam and hip-pocampus) of male albino rats. The increase in NE, DA, 5-HT, and GABA content in the different CNS areas of male albino rat may be due to the inhibition of Ca2+/calmodulin binding which plays an important role in the release of these neurotransmitters. The results, also, revealed that urea and creatinne con-centrations in rats with oral administration with olive oil were decreased. Meanwhile, the activities of the enzymes AsT, AlT and ALP were elevated. The pre-sent results indicated that there is no change in tis-sues of kidney after treated with virgin olive oil. Olive oil may potentially be safe for use as a sedative drug. improvement also led to the reductions in risk of Alzheimer’s and Parkinson’s diseases