Antimicrobial Activity of Date Palm (Phoenix Dactylifera) Pits Extracts and Its Role in Reducing the Side Effect of Methyl Prednisolone on Some Neurotransmitter Content in the Brain, Hormone Testosterone in Adulthood

Abstract

The present work was carried out to study the impact of date palm pits as antibacterial activities on two species of pathogenic bacteria (klebsiella pneumonia and Escherichia coli) and its role in reducing side effect of methylprednisolone on the some neurotransmitter content in the brain, hormone testosterone and testclture of male albino rats .Date palm pits is most effective in inhibiting growth of bacteria as compared with antibiotics due to differences in resistance of bacteria to anti-tested materials due to change in membrane permeability of cells, thereby hindering the entry of enzymes or excreted by the change in the chemical composition of the constituent chemical. The results showed that the daily oral administration of pits of date palm caused the maximal increase in NE, DA& GABA content was found in the brain stem after 2 weeks. The daily oral administration of methylprednisolone caused decrease in NE,DA& GABA content was found in the brain stem after 2 weeks. Moreover, the daily oral administration of pits of date palm and methylprednisolone caused increase in NE content was found in the brain stem after 2 weeks. The daily oral administration of pits of date palm and methylprednisolone caused a significant increase in testosterone level in serum blood of male albino rat. From the present results, it is clear that Effect of chronic oral administration of methylprednisolone and pits of data palm on testicular of male albino rat caused recovery effect, notice high sperm in some tubules and tubular partial late spermatogenic arrest (spermatide level) is only seen in 10-20% of tubules. The appropriate recommendations in this study to use nuclei dates Antimicrobial on klebsiella pneumonia and Escherichia coli than the activity of standard antibiotics and the results concluded that using intended dates date palm pits as a preventive measure to reduce the side effects resulting from the use of a drug methylprednisolone on the some neurotransmitter content in the Brain. Hormone Testosterone and testclture in male albino rats.

Chemical Compositions of Date-Pits and Its Potential for Developing Value-Added Product - a Review

“…Water and alcoholic extracts of date-pits showed anti-microbial activity against Klebsiella pneumonia, Escherichia coli [Mossa et al, 1986], Staphylocaccus aurus, Proteus vulgaris, and Bacillus subtilis [Saddiq & Bawazir, 2010]. Date-pits are most effective in inhibiting the growth of bacteria as compared to antibiotics, mainly due to two reasons: i) differences in resistance of bacteria to anti-tested materials, and ii) the change in membrane permeability of cells, thereby hindering the entry of enzymes or excreted by the change in the chemical composition of the constituent chemical [Mossa et al, 1986;Saddiq & Bawazir, 2010].…”

“…Date-pits are most effective in inhibiting the growth of bacteria as compared to antibiotics, mainly due to two reasons: i) differences in resistance of bacteria to anti-tested materials, and ii) the change in membrane permeability of cells, thereby hindering the entry of enzymes or excreted by the change in the chemical composition of the constituent chemical [Mossa et al, 1986;Saddiq & Bawazir, 2010].…”

Role of Phoenix dactylifera in ameliorating Eimeria papillata-induced hepatic injury in mice

“…Its extract was found to exhibit strong antimicrobial activity against various types of microorganisms such as, bacteria (Saddiq and Bawazir, 2010), fungi (Shraideh et al, 1998) and viruses (Jassim and Naji, 2010). Also, date palm extract was found to have a strong hepatoprotective activity against various harmful toxicants (Saafi et al, 2011;Al-Qarawi et al, 2005) from results obtained from histological and biochemical measurements.…”

Comparative Study of Antibacterial Activity of Plant Ex-Tracts From Several Regions of Asia

“…The lack of activity may also be due to the solvent used and the type of bacteria. Saddiq and Bawazir (2010), for example, found that Klebsiella pneumonia and Escherichia coli growth was inhibited by treatment with P. dactylifera water extracts, with inhibition zones of 16.351 and 10.00 mm, respectively. Further, an acetone extract of P. dactylifera was shown to be a potential antiviral agent against pathogenic human viruses (Jassim and Naji, 2007).…”