Presense of thrombocytosis and idiopatic thrombosis can suggest occult malignancy. It would be prudent to further evaluate the relationship of trombotic events, trombocitosis and head and neck tumors. We suggest anticoagulants to prevent thromboembolic complications, affect the angiogenesis and prevent development of metastatic disease. It may lead to lower mortality rate.
There is no space for rationalizing the costs of anesthetics and other drugs in anesthesia.
It is possible to miss an awareness episode without using bispectral index technology monitoring during general anaesthesia in otorhinolaryngology and maxillofacial surgery. Bispectral index monitoring should be the clinical standard in general anaesthesia.
It is possible to overdose anesthetic drug during surgery without using bispectral index technology monitoring during general anesthesia in otorhinolaryngology maxillofacial surgery. Bispectral index monitoring should be the clinical standard in general anesthesia.
SUMMARYTopic: Comorbidities, simultaneous occurrence of two or more disorders are common in psychiatry; therefore the concept of dual diagnosis was established due to new ethiopatogenetic dilemmas and principles of diagnosis and treatment of these conditions. The most common are comorbid aff ective disorders and comorbidity of drug addictions and aff ective disorders. Topic position in medical public: Epidemiological studies show a high percentage of comorbidity of drug addictions and depression. Various studies show that about one-third of individuals with depression have addiction, and often some other psychiatric disorders are present, such as personality disorder, anxiety, and bipolar aff ective disorder. Comorbid disorders exacerbate one another; have tendencies to chronicity and treatment resistance. The problem of adequate diagnosis is common; other diagnosis is neglected, leading to inadequate treatment and poor outcomes. Researches of possible causes of addiction and depression comorbidity follow diff erent theoretical assumptions. One favor genetically determined vulnerability, the others are addressing to the impact of trauma in the formative stages of personality development. Widespread is the theoretical assumption on the defi cit functioning of the same regions of the CNS and the same neurotransmitters system. In previous studies the preclinical ones dominate, which are theoretically placed in the context of the CNS of a man. Most of the research are related to dysfunction of the serotonergic and dopaminergic systems, whose infl uence on addiction and depression are clear, and recent studies show the importance of neuromodulators and their receptors, for example, the role of natural opioid dynorphin and "kappa" receptors in the mesolimbic reward system. Further action: The better diagnosis would require proper screening of patients entering addiction treatments for aff ective disorders and vice versa. Treatment have to be combined; in addition to medications for addiction essential are antidepressants, atypical antipsychotics, and/or mood stabilizers, for better therapeutic results.
Introduction: Pharmacotherapy dealing with drug research is extremely complex process because in addition to basic knowledge in pharmacology, it includes both knowledge in clinical medicine and medical statistics. Methods: Statistical methods applied in medical research have been studied on examples of individual statistical methods applied in particular clinical trials. Topic: The following problems have been discussed: study design, study plan, criteria for selecting patients, the required and suffi cient minimum number of patients in the clinical trial, the selection of the most commonly used descriptive and analytical statistical procedures, but also a critical review of analytical statistical procedures that have great potential in checking the conformity of everyday clinical practice with evidence-based medicine. Conclusions: Knowledge of statistical methods is a valuable companion and tool of clinicians, since it enables them to carry out appropriate research with the best possible conclusions based on medical evidence.
Introduction: Benzodiazepines belong to the group of anxiolytic sedatives and the most prescribed drugs in the world. The authors conducted this pilot study based n large number of patients reports that they were less anxious and felt better overall by migrating to sunnier environments. Aim: We estimated the impact of the total sunshine hours per month on daily exposure of the population to Benzodiazepine anxiolytic on a monthly basis in the Republic of Serbia. Material and Methods: We conducted a retrospective academic IV phase study, which tested the correlation of time series of monthly sold Benzodiazepine anxiolytics in pharmacies and total sunshine hours per month in the Republic of Serbia, from January 2014 to May 2019. Results: According to the seasons, we did not find any difference in the increase of the population exposure to benzodiazepines. A difference was found between bromazepam consumption compared to cumulative monthly. Bromazepam consumption was negatively correlated with the cumulative monthly sunshine hours. The cutoff value for bromazepam was 131.45 cumulative monthly sunshine hours. Conclusion: This is the first pharmaco-epidemiologic study to prove that the population's exposure to benzodiazepines, in addition to the implicit health and economic effects on physicians' prescribing habits for these drugs, can be independently linked to the cumulative effects of monthly sunshine hours on the population. No difference in Benzodiazepine consumption was found in relation to the seasons (spring/summer vs autumn/winter). In months where sunshine hours was ≥135.45, the need for bromazepam was significantly reduced. Seasonal variation of climatic effects of total monthly sunshine hours is significantly correlated with the population's need for benzodiazepines with anxiolytic effects longer than 12 hours.
It has been concluded that the increase of absorbed radiation dose in vitro leads to prolonged duration of cell cycle in the same conditions, which proves cytostatic effect of radiation. Further fundamental studies are required for clinical implementation of the findings.
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