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Oxidative stress has received a considerable scientific attention as a mediator in the etiology of many human diseases. Oxidative stress is the result of an imbalance between free radicals and antioxidants. Cells can be damaged by free radicals that are considered to play a main role in the aging process and diseases development. Antioxidants are the first line of defense against the detrimental effects of free radical damage, and it is essential to maintain optimal health via different mechanisms of action. Types of antioxidants range from those generated endogenously by the body cells, to exogenous agents such as dietary supplements. Antioxidant insufficiency can be developed as a result of decreased antioxidant intake, synthesis of endogenous enzymes, or increased antioxidant utilization. To maintain optimal body function, antioxidant supplementation has become an increasingly popular practice through improving free radical protection. In this chapter, we first elucidate the oxidative stress, and then define the antioxidant and its categories. Finally, introduce the antioxidants mode of actions for cell protection from free radicals.

Background: Cerebral Palsy is a group of disorders that affect the development and growth of the movement leading to the determination in the activities of the body, especially related to movements. These disorders occur as a result of damage or deterioration in certain parts of the brain. Objective: To evaluate the effectiveness of horse riding simulator with strengthening training program on children with spastic diplegic cerebral palsy and comparing it with conventional physiotherapy program which is used in rehabilitation. Patients and Methods: Thirty participants were recruited in this study, who were diagnosed with spastic diplegic cerebral palsy. Their ages between four and twelve years old, the children were randomly classified into three groups of interventions Horse Riding Simulator with Strengthening Training, Horse Riding Simulator with conventional physiotherapy and control group with conventional physiotherapy).for each intervention, the children receive 24 sessions three times a week, [Gross Motor Function Measure-66, pediatric balance scale, and Modified Modified Ashworth Scale] were used to evaluate children in all groups both pre and post each intervention.

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