Antioxidant Categories and Mode of Action

Aziz, Manal Azat; Diab, A.; Mohammed, A.

doi:10.5772/intechopen.83544

Cited by 45 publications

(38 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antioxidants, which are divided in two classes, protect organisms from oxidative damage by free radicals [29]. The enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) belong to the first category, while the second one is found in exogenous sources, such as dietary supplements [29].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity of Different Tissues from Rabbits Fed Dietary Bovine Colostrum Supplementation

Serra

Castrica

Agradi

et al. 2023

Animals

View full text Add to dashboard Cite

Recent advances in animal nutrition have indicated that bovine colostrum (BC), due to its content of macronutrients, micronutrients and bioactive compounds, is an excellent health supplement. To the best of our knowledge, no studies on the effect of BC on antioxidant status have been performed in rabbits. This study aimed to investigate the effect of two BC concentrations on antioxidant status and gene expression of antioxidant enzymes in some tissues of rabbits. Thirty New Zealand White male rabbits were randomly divided into three experimental diets, containing 0% (CON), 2.5%, and 5% of BC (BC-2.5 and BC-5, respectively). The activity of antioxidant enzymes in plasma (catalase: CAT; glutathione peroxidase: GPx; superoxide dismutase: SOD), and the enzymes’ gene expression in the liver and longissimus dorsi muscle, were determined. Results showed no significant differences, neither in plasma nor in tissues. A significant tissue-related effect has been observed regarding the mRNA levels of SOD and GPx, which were higher in the LD (p = 0.022) and liver (p = 0.001), respectively. Further studies, considering modifications of the length and dosage of dietary BC supplementation, are required to update the current state of knowledge in rabbits, as well as to fully understand the potential value of BC for possible application in farming use.

show abstract

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity of Different Tissues from Rabbits Fed Dietary Bovine Colostrum Supplementation

Serra

Castrica

Agradi

et al. 2023

Animals

View full text Add to dashboard Cite

show abstract

“…Enzymatic antioxidants are antioxidants that involve several enzymes such as GPx, CAT and SOD in catalyzing free radical and ROS neutralization reactions, while non-enzymatic antioxidants can come from natural materials such as fruits, onions and others. These natural materials contain several compounds that have antioxidant activity such as flavonoids, alkaloids, carotenoids and phenolic groups [ 111 ]. Testing of antioxidant activity can be carried out by some test methods such as DPPH free radical scavenging assay, oxygen radical absorbance capacity (ORAC) assay, trolox equivalent antioxidant capacity (TEAC) assay, ferric reducing antioxidant power (FRAP) assay, cupric reducing antioxidant capacity (CUPRAC) assay, reducing power assay and other methods [ 112 , 113 , 114 ].…”

Section: Antioxidant Propertiesmentioning

confidence: 99%

Antioxidant Properties and Structure-Antioxidant Activity Relationship of Allium Species Leaves

et al. 2021

View full text Add to dashboard Cite

Allium is a genus that is widely consumed and used as traditional medicine in several countries. This genus has two major species, namely cultivated species and wild species. Cultivated species consist of A. cepa L., A. sativum L., A. fistulosum L. and A. schoenoprasum L. and wild species consist of A. ursinum L., A. flavum L., A. scorodoprasum L., A. vineale L. and A. atroviolaceum Boiss. Several studies report that the Allium species contain secondary metabolites such as polyphenols, flavonoids and tannins and have bioactivity such as antioxidants, antibacterial, antifungal, anti-inflammatory, pancreatic α-amylase, glucoamylase enzyme inhibitors and antiplatelets. This review summarizes some information regarding the types of Allium species (ethnobotany and ethnopharmacology), the content of compounds of Allium species leaves with various isolation methods, bioactivities, antioxidant properties and the structure-antioxidant activity relationship (SAR) of Allium compounds.

show abstract

“…11 Plant antioxidants like polyphenols, carotenoids, glutathione have exhibited antioxidant effects by interrupting free radicals’ chain reactions. 12 Due to these properties, plant antioxidants are being considered as a source of alternative and complementary therapy against oxidative stress. Natural antioxidants have been discovered in medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Phytochemical Profile and In Vitro Antioxidant Properties of Ethyl Acetate Extracts of Xerophyta spekei (Baker) and Grewia tembensis (Fresen)

Nyalo

Omwenga

Ngugi

2023

J Evid Based Complementary Altern Med

View full text Add to dashboard Cite

Overproduction of free radicals in excess of antioxidants leads to oxidative stress which can cause harm to the body. Conventional antioxidants have drawbacks and are believed to be carcinogenic. The present study seeked to confirm folklore use and validate the antioxidant potentials of Grewia tembensis and Xerophyta spekei which have been widely used in the Mbeere community as medicinal plants. Antioxidant properties were determined through scavenging effects of diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide radicals as well as iron chelating effects. The data obtained was assayed in comparison to the standards (Ascorbic acid and EDTA). Ascorbic acid had a significantly greater DPPH radical scavenging property with an inhibitory concentration (IC50) value of 20.54 ± 2.24 µg/mL in comparison to the plant extracts, which had IC50 values of 33.00 ± 1.47 µg/mL, 69.66 ± 1.01 µg/mL and 86.88 ± 2.64 µg/mL for X. spekei, G. tembensis leaf and G. tembensis stem bark extracts, respectively. EDTA demonstrated a significantly greater iron chelating effect having a significantly lesser IC50 value of 25.05 ± 0.79 µg/mL as opposed to 43.56 ± 0.46 µg/mL, 89.78 ± 0.55 µg/mL, and 120.70 ± 0.71 µg/mL for X. spekei, G. tembensis leaf, and G. tembensis stem bark extracts respectively. Additionally, ascorbic acid also exhibited stronger hydrogen peroxide radical scavenging effect than the studied extracts. Generally, X. spekei extract had higher antioxidant activities as compared to both the leaf and stem bark extracts of G. tembensis. The phytochemical screening demonstrated the presence of secondary metabolites associated with antioxidant properties. The present study therefore, recommends ethno medicinal and therapeutic use of G. tembensis and X. spekei in the treatment and management of oxidative stress related infections.

show abstract

Antioxidant Categories and Mode of Action

Cited by 45 publications

References 57 publications

Antioxidant Activity of Different Tissues from Rabbits Fed Dietary Bovine Colostrum Supplementation

Antioxidant Activity of Different Tissues from Rabbits Fed Dietary Bovine Colostrum Supplementation

Antioxidant Properties and Structure-Antioxidant Activity Relationship of Allium Species Leaves

Quantitative Phytochemical Profile and In Vitro Antioxidant Properties of Ethyl Acetate Extracts of Xerophyta spekei (Baker) and Grewia tembensis (Fresen)

Contact Info

Product

Resources

About