Background: Weather a psychological construct or a clinical entity, numerous studies have been focused on the biological link between stress, burnout, and biomarkers. Aim: The purpose of our study was to search the existing literature and summarize the immunological and endocrine alterations found in burnout patients and, also, to provide updated data for clinicians to use. Methods: We performed a literature search in PubMed database using specific terms. Results: The primary focus of the literature seems to be the hypothalamic-pituitary-adrenal (HPA) axis, which may be affected due to chronic stress, which can be investigated by measuring hormonal responsiveness [corticotropinreleasing hormone (CRH), adrenocorticotropic hormone (ACTH), cortisol, prolactin, thyroid hormones]. An important challenge that this field is faced with is the pulsatile and diurnal fluctuation of them, which may not always be considered and the heterogeneity of burnout measurements. Many studies have explored the linking pathways between the immune system and chronic stress, but only a few have specifically evaluated this process for future diagnostic or prognostic biomarkers. Conclusions: Burnout has cumulative effects on our body and stress does not affect us in a singular direction, on the contrary, significant clinical implications are found, not only microscopic, but affective symptoms leading to anxiety and depression.
The coronavirus pandemic has had a global impact on both mental and physical health. Caregiving has become more difficult during this time due to the quick spread of this respiratory disease, dread of the unknown, congested hospitals, and many restrictions, particularly for people with multiple comorbidities. We aimed to assess the impact of this pandemic on a group of caregivers of patients with dementia and their needs during this time. The study’s findings indicate that females assumed the role of the caregiver more often than men (88.5% of the participants) and scored lower on the life quality scale. The most often issue encountered during the pandemic was difficulty in accessing health care facilities (36%). Participants with a higher education level scored better in the physical (24.67, p = 0.01 and 24.48, p = 0.01) and mental health (20.67, p = 0.002; 19,82, p = 0.008) domains of the life quality test. The fear of COVID questionnaire showed a low level of concern in the category of participants with a high education level. Overall, this pandemic emphasizes the importance of social interaction and the possibilities to improve health care services through telemedicine. Caregivers could benefit from socialization and support programs as well as the early detection of affective disorders.
The study objective is the correlation of thyroid function to the weight status in a study group made up of schoolchildren in Galati County. Six of ten overweight children before puberty will became obese during adulthood. PREDATORR study published in May 2014, placed our country in the top among overweight and obesity European incidence, showing a 34.7% prevalence of overweight and 31.9% obesity in subjects in the age group 20-79 years. Unfortunately the study did not offer epidemiological data regarding children population. The data obtained allow the characterization of the thyroid function in relation to weight status in school age children, in a county both in urban and rural area, taking in account that there are fewer studies in rural in this moment. It brings further information on thyroid function and pathology in pediatric obesity in relation to metabolic comorbidities. We identified an increased fT3 and TSH in obese children, sustaining the association between dyslipidemia, thyroid function, anxiety and depression, as long as the data obtained adult are still controversial.
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