We have registered 2,064 cases of cancer among the inhabitants of Conakry, Guinea, during 1992-1994, corresponding to age-standardized incidence rates (ASRs) of 83.3 per 100,000 in men and 110.5 per 100,000 in women. As elsewhere in West Africa, the principal cancer of men was liver cancer (ASR 32.6), with modest rates of stomach (ASR 6.2) and prostate (ASR 8.1) cancers. In women, cervix cancer was the dominant malignancy (ASR 46.0), followed by liver cancer (ASR 12.5) and breast cancer (ASR 10.9). In contrast to contemporary East and Central Africa, Kaposi's sarcoma remained rare (only 4 cases). In the childhood age group, relatively high incidence rates were found for Hodgkin's disease, Burkitt's lymphoma and, especially, retinoblastoma.

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The effects of long-term incorporation of organic manure and biofertilizers have been investigated on winter wheat in the North China Plain (NCP). The five-year field experiment (2013–2018) has illustrated the responses of grain yield and yield components. Seven fertilization approaches, included pig farm-yard-manure and biofertilizers amendments combined with five NPK% drop levels of chemical fertilizer ratio + organic fertilizer + biofertilizer (0, C+O+B) 25%, CL4; 50%, CL3; 75%, CL1; and 100%, CL0), without fertilizer as control (CK), in NCP during the years 2013–2018. Results showed that the grain yields of CL1 and CL2 were equivalent to CL0 in all growing seasons except 2014/2015. The grain yields of CL4 were 29.9% to 46.6% lower than that of CL0 during 2014/2015, 2016/2017, and 2017/2018. The valuable spike-number, grain number per-spike, and 1000-grain weight showed significant variations among different growing periods. Regression analysis of grain yield and yield components indicated that number grains per-spike showed significant increase in seed yield formation. The 1000-grain weight was the major parameter that influenced yield of moderate and low yielding periods, respectively. The results revealed that application of 30 m3 ha−1 pig farm-yard-manure and 20 kg ha−1 biofertilizers has reduced at least 50% of the NPK fertilization without dropping grain yields in the North China Plain.

BRCA1 and BRCA2 are the most incriminated genes in inherited breast/ovarian cancers. Several pathogenic variants of these genes conferring genetic predisposition have been described in different populations but rarely in sub-Saharan Africa. The objectives of this study were to identify pathogenic variants of the BRCA genes involved in hereditary breast cancer in Senegal and to search for a founder effect. We recruited after free informed consent, 27 unrelated index cases diagnosed with breast cancer and each having a family history. Mutation screening of the genes identified a duplication of ten nucleotides c.815_824dupAGCCATGTGG, (p. Thr276Alafs) (NM_007294.3) located in exon 11 of BRCA1 gene, in 15 index cases (allelic frequency 27.7%). The pathogenic variant has been previously reported in African Americans as a founder mutation of West African origin. Haplotypes analysis of seven microsatellites surrounding the BRCA1 gene highlights a shared haplotype encompassing~400 kb between D17S855 and D17S1325. This haplotype was not detected in none of 15 healthy controls. Estimation of the age of the pathogenic variant suggested that it occurred~1400 years ago. Our study identified a founder pathogenic variant of BRCA1 predisposing to breast cancer and enabled the establishment of an affordable genetic test as a mean of prevention for Senegalese women at risk.npj Genomic Medicine (2020) 5:8 ; https://doi.