The biogenesis of the mould metabolites rotiorin (11), monascin (111), and rubropunctatin (IV) has been examined by using Me*14C02H and HJ4C02H. In agreement with prediction they arise in part from both sources. The extent of introduction of label from Me*14C0,H into different parts of the molecule does not vary significantly.
INSPECTION of the formula (I) of terrein, fromAsfiergillus teweus Thom, suggests that it arises at least partly by the polyketide-fatty acid route.It is unusual in containing a five-membered ring since polyketides normally contain six-membered ones if any, because they are connected with
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