and immunochemical determination27-3b), the significance of the results has not been fully appreciated, and the data have sometimes been inconclusive.Study of the literature devoted to this subject is diacult because the selection of patients has varied and because clinical criteria have varied from one author to the next.Few authors have employed more than one technique on the same CSF sample except to compare the colloidal c u r v e s 5~8~9~1 0~~6~2 8 to one of the newer techniques. It is clear that there is need for reevaluation of existing literature.The present work is based on results obtained by agar gel electrophoresis and is concerned with a correlation between clinical parameters and different electrophoretic patterns of CSF proteins. hlATERIALS AND METHODSPatient population. We reviewed the records of 2,043 patients who had been admitted to 982Neurology / Volume 20 / October 1970 the Neurological Department of the University Clinics and in whom CSF protein electrophoresis was performed. In 323 patients, the diagnosis was multiple sclerosis, designated as either definite, probable, or possible. The other patients were assigned to one of the diagnostic categories listed in Table 1. The diagnoses were based on clinical examination and technical procedures such as myelography, pneumoencephalography, arteriography, cerebral scintigraphy, electroencephalography, and routine CSF examination. The results of CSF protein electrophoresis were not considered in making the diagnosis. The different clinical and laboratory data concerning these cases of MS were plotted on IBM cards.Tentative correlations were established between electrophoretic patterns of CSF proteins and the duration and course of the disease, degree of disability, and diagnostic category, as well as the CSF cell count and total protein content. No attempt was made to categorize

No abstract

No abstract

No abstract