Opsoclonus secondary to an Epstein-Barr virus infection

Delreux, V.; Kevers, Laurent; Sindic, Christian; Callewaert, A.

doi:10.3109/01658108808996039

Cited by 7 publications

(6 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore we evaluated intrathecal IgG production as oligoclonal IgG bands in CSF. OCBs in OMS patients are rarely reported [1,9,12,13], in other cases OCBs were not detected [33,40,45]. The number of bands is of unclear relevance, but the sequential detection of OCBs in the same patient may hint at individual alterations in the immune system within the CNS.…”

Section: Discussionmentioning

confidence: 96%

“…To our knowledge, intrathecal synthesis of IgM, G and A has not been thoroughly addressed in OMS.Several patients had raised IgG concentration in CSF [6,12,14,18,30]. The transient rise in CSF immunoglobulins IgG and IgM and in CSF plasmocytes was observed in opsoclonus associated with Hemophilus influenzae meningitis [33].…”

Section: Discussionmentioning

confidence: 96%

“…Identification of the specific microorganism is, however, very rare [3,7,12,13,20,30,35,40,45]. OMS is assumed to be immune mediated [13,23,31,47].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Opsoclonus—myoclonus—dysequilibrium syndrome: cytological and immunological dynamics in the serial cerebrospinal fluid in two patients

Bartoš

Piťha

2003

J Neurol

View full text Add to dashboard Cite

A peculiar clinical presentation characterized by the triad of opsoclonus,myoclonus and ataxia, mainly in a form of dysequilibrium, is usually associated with infectious or paraneoplastic processes. Serial cerebrospinal fluid (CSF) analysis in two patients with opsoclonus-myoclonus-dysequilibrium syndrome suggestive of viral encephalitis were performed from disease onset for up to 8 months. A cell count, cytology, total protein and glucose concentrations in CSF, the blood-CSF barrier function, intrathecal synthesis of immunoglobulins (Ig) in class M, G and A expressed as IgM, IgG and IgA indices and oligoclonal IgG bands were monitored. Cellular and humoral alterations in both patients were slight at the onset becoming more pronounced a month later. The kinetics of the CSF changes mirrored the subacute clinical deterioration and subsequent recovery. The delayed response in the CSF measures and the gradual clinical deterioration suggest the development of subacute brain inflammation. A mononuclear pleocytosis, including macrophages and plasma cells, increased within the first month and then normalized during the following weeks. Intrathecally synthesized IgM occurred only transiently after one month of illness, whereas intrathecal IgG production increased during the first month and persisted for at least eight months. An increasing number of oligoclonal IgG bands during the course, indicative of expanding local intrathecal synthesis, was noted. The dynamics of these CSF changes supports the hypothesis that opsoclonus-myoclonus syndrome is a post-infectious immune- mediated condition.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Opsoclonus—myoclonus—dysequilibrium syndrome: cytological and immunological dynamics in the serial cerebrospinal fluid in two patients

Bartoš

Piťha

2003

J Neurol

View full text Add to dashboard Cite

show abstract

“…Sirs: Opsoclonus syndrome is the occurrence of involuntary, repetitive, rapid conjugate ocular saccades that are irregular in amplitude and frequency and occur in all directions without an intersaccadic interval [1][2][3][4][5]. Although opsoclonus is the only universal component of this syndrome, it may be accompanied by other neurological signs such as myoclonus, ataxia, tremor, gait and stance dysfunction, dysarthria and decreased mental status [1].…”

mentioning

confidence: 99%

“…Although opsoclonus is the only universal component of this syndrome, it may be accompanied by other neurological signs such as myoclonus, ataxia, tremor, gait and stance dysfunction, dysarthria and decreased mental status [1]. The most common aetiologies are idiophatic, paraneoplastic and infectious encephalitis [1][2][3][4][5]. Opsoclonus secondary to Epstein-Barr virus infection has been rarely described [2,5].…”

mentioning

confidence: 99%