I (t-Butyl-amino-3-ol-2-propyl) oximino-9 fluorene is a new P2-adrenoceptor blocking agent with a pA2 of 9.23 ± 0.25 on isolated trachea.2 It provokes hypertension in normotensive rats and does not prevent arterial hypertension in SHR rats, although it does prevent the renin secretion normally induced by isoprenaline infusion.
Multifocal motor neuropathy (MMN) is typically associated with distal upper limb weakness and wasting. However, proximal muscle bulk, particularly of biceps brachii, may be well preserved even in the presence of severe proximal weakness. Here we report 3 patients with MMN who had true muscle hypertrophy of severely weakened biceps muscles and positive motor symptoms including cramp and fasciculations in these muscles. Electromyographic studies demonstrated markedly impaired recruitment in the affected muscles and continuous motor unit activity comprising multiple fasciculation potentials at a frequency of up to 30 per minute. We propose that this continuous motor unit activity may have contributed to the hypertrophy in these muscles.
SUMMARY1. The 02 tension of umbilical arterial blood in utero is 15 mmHg. The contractile effect of increasing the 02 tension above this value was studied quantitatively in vitro in preparations of human umbilical artery and vein.2. The umbilical arterial smooth muscle was contracted in a concentration-related manner by stepped increments in 02 tension. The threshold for O2-induced contraction was estimated to be 36 mmHg at pH 7-28 and the maximum contraction occurred at 297 mmHg.3. The sensitivity of the preparations to low 02 tensions (<100 mmHg) was reduced by increasing the pH of the bathing medium from 7-28 to 7-36, at which the threshold was 69 mmHg and the maximum contraction occurred at 282 mmHg.Reducing the pH to 7418 did not significantly change the sensitivity from that found at pH 7-28.4. Indomethacin (0-1 ,tM) virtually abolished responses to 025. The results indicate that the increase in the physiological 02 tension at birth, from 15 to 100 mmHg, may be an adequate stimulus to effect the closure of the umbilical artery.6. In the physiological range 02 did not contract the umbilical venous smooth muscle. This may allow the transfusion of blood from the placenta to the fetus at birth when the 02 tension of umbilical cord blood increases after the onset of breathing.
Background An interaction between fusidic acid and HMG coenzyme A reductase inhibitors (statins), resulting in rhabdomyolysis, has been described. Pain and mild weakness are common presenting symptoms.
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