I (t-Butyl-amino-3-ol-2-propyl) oximino-9 fluorene is a new P2-adrenoceptor blocking agent with a pA2 of 9.23 ± 0.25 on isolated trachea.2 It provokes hypertension in normotensive rats and does not prevent arterial hypertension in SHR rats, although it does prevent the renin secretion normally induced by isoprenaline infusion.

1 The inhibitory effects were studied of 4 P-adrenoceptor antagonists against renin release induced by isoprenaline (0.5 iimol/l) in rat kidney slices. Additionally the pA2 values of these 4 drugs were measured against isoprenaline in guinea-pig isolated atria and trachea (against fl1-and fl2-adrenoceptors respectively). 2 When employed at a concentration of 2 jimol/l propranolol and atenolol significantly inhibited renin release (P < 0.001 and P < 0.01) whereas practolol and IPS 339 [t-butyl-amino-3 ol-2 propyl) oximino-9 fluorene] had little effect. 3 A positive correlation was shown between the degree of inhibition of renin release and the pA2 of the antagonists at the f3l-adrenoceptors.4 When practolol and IPS 339 were used in equipotent molar concentrations to propranolol for the Pl-adrenoceptors they inhibited renin release.5 The results suggest that the adrenoceptor involved in the renin release induced by isoprenaline in the rat kidney is of the P1-type.

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Trace amounts of two unknown trypsin-inhibiting fractions have been separated from pooled human serum by DEAESephadex chromatography. They are immunologically different from oq-antitrypsin, oq-macroglobulin or inter-a-trypsin inhibitor and they form two well separated peaks after rechromatography on DEAE-Sephadex column. Both of these fractions also inhibit Chymotrypsin but not elastase. Their relation to other trypsin inhibitors of human serum is discussed.