Eleven boys aged 1-10 years with central precocious puberty were studied. According to the pubertal development six were classified as P2, one as P3 and four as P5. In all cases plasma testosterone levels were definitely elevated (1.7-5.8 ng/ml) when compared with pre-pubertal controls. Peak values after HCG (3 X 1500 units) in four of the boys were in the high adult range. The binding capacity of serum testosterone oestradiol binding globuline (TeBG) ranged between 0.5 and 7.30 microgram/dl. Basal plasma levels of LH and FSH were respectively 2.06 +/- 0.64 and 1.2 +/- 0.25 miu/ml, and peak levels after LHRH (0.1 mg/m2) 13.9 +/- 3.7 and 2.6 +/- 0.43 miu/ml respectively. The data demonstrated a significant increase of plasma testosterone and post LHRH LH peak levels in boys with central precocious puberty when compared with pre-pubertal controls. The patients at stage P2 exhibited high levels of plasma testosterone contrasting with the degree of pubertal maturation, high values of TeBG and low response to LHRH which were in the pre-pubertal range. These findings suggest that the testicular sensitivity to LH increases early in boys with central precocious puberty, while the testosterone responsiveness, both at peripheral and hypothalamic levels, is delayed.
Specific insulin binding to erythrocytes was studied in 5 infants with nesidioblastosis and in 15 controls. A close correlation was found between the binding and the reticulocyte count in controls. According to the number of reticulocytes in their blood, 2 patients had increased binding, related to an increased number of high-affinity sites. In 3 patients studied after therapy, the binding was similar to controls, the affinity of high-affinity sites being decreased when their number remained unchanged.
Serum TeBG binding capacity was measured in 8 cord blood samples, and in peripheral venous blood from 39 male and 31 female infants aged from 1 day to 1 year. In cord blood, TeBG binding capacities were low (1.27 +/- 0.3 microgram/100 ml) with no sex difference. In male infants, TeBG binding capacities increased progressively from birth to 3 months, before decreasing to reach the normal prepubertal level at 6 months. Individual values ranged between 1.16 and 14.5 microgram/100 ml and were significantly correlated with plasma testosterone (r = 0.671, 95% confidence limits 0.440 to 0.818, p less than 0.005) and estradiol (r = 0.734, 95% confidence limits 0.121 to 0.942, p less than 0.01) levels. In female infants, individual values ranged between 1.17 and 14.5 microgram/100 ml, without correlation with age or plasma estradiol level. In male infants the data suggest a positive control ot TeGB binding capacity by estrogens, the negative effect of testosterone being delayed until after the 3rd month of age. In girls, the lack of correlation between TeBG and estradiol can probably be explained by rapid variations of plasma estradiol levels.
y s t a t h i o n i n e and t a u r i n e i n human b r a i n d u r i n g e a rl y f o e t a l development.The d e v e l o p m e n t a l changes i n t h e c o n c e n t r a t i o n of L -c y s t a t h i o n i n e and t a u r i n e i n hunan f o e t a l b r a i n t i ss u e were examined d u r i n c t h e f i r s t and second t r i m e st e r , which i s t h e p e r i o d of i n t e n s i v e n e u r o n a l g r o w t h and m u l t i p l i c a t i o n . B r a i n t i s s u e s a m p l e s were o b t a ined from 14 f o e t u s e s ( crown-rump l e n g t h 2.5-21 cm ) a t l e g a l t h e r a p e u t i c a b o r t i o n s . T i s s u e specimens were i n . o e d i a t e l y p r e p a r e d f o r amino a c i d a n a l y s e s which were performed by a u t o m a t i c column chromatography. There was v i r t u a l l y no L -c y s t a t h i o n i n e i n .ih'ole-brain t i s s u e from t h e s m a l l e s t f o e t u s ( crown-rump l e n g t h 2 . 5 cm ) . Throughout t h e f i r s t and seconu t r i a l e s t e r a s t e a d y i n c r e a s e i n t h e c o n c e n t r a t i o n of L -c y s t a t h i on i n e o c c u r r e d i n f o e t a l b r a i n s . The amount of t a u r i n e was h i g h i n b r a i n t i s s u e from t h e s m a l l e s t f i r s t -t r im e s t e r f o e t u s : some i n c r e a s e o c c u r r e d j u r i n g f i r s t and second t r i m e s t e r . J u r i n g e a r l y f o e t a l development t h e c o n c e r i t r a t i o n of t a u r i n e i n hunan b r a i n was h i g he r t h a n p r e v i o u s l y r e p o r t e d amounts d u r i n g p e r i n a t a l p e r i o d and a d u l t l i f e . The d i s t r i b u t i o n of L -c y s t at h i o n i n e and t a u r i n e i n b r a i n t i s s u e d u r i n g l a t e mi3-t r i m e s t e r d i f f e r e d from t h a t o b s e r v e d i n a d u l t hunans. bv H.K.A. V i s s e r ) . "La F e " C h i l d r e n ' s Hosp i t a l V a l e n c i a , S p a i n .~n t r a u t e r i n e bone growth. At b i r t h , growth and m a t u r a t i o n of t h e newborn a r e u s u a l l y a s s e s s e d by c l i n i c a l , a n t h r o p o m e t r i c and neurol o g i c a l e x a m i n a t i o n s . A new q u a n t i t a t i v e and o b j e c t i v e method i s p r e s e n t e d : t h e l e n g t h of c u b i t u s and r a d i u s . A t o t a l of 156 newborns, 75 m a l e s and 81 f e m a l e s a p p r o p i a t e f o r g e s t a t i o n a l a g e (AGE), from t h e 2 4 t h t h r o u g h t h e 4 0 t h week of g e s t a t i o n w e r e s t u d i e d . Three i n d e p e n d e n t i n v e s t i g a t o r s p a r t i c i p a t e d i n t h e c o l l e c t i o n of t h e d a t a , o n l y one of them, by n e c e s it y , knew t h e d a t e of t h e l a s t m e n s t r u a l p e r i o d . Bone l e n g t h was measured by a "DIAL CALIPER HELIOS" w i t h a s e n s i t i v i t y of m e t e r s . Bone growth i n l e n g t h from t h e 24th t h r o u g h t h e 4 0 t h week i s a li n e a r f u n c t i o n w i t h a p p a r e n t l y two d i f f e r e n t s l o p e s , one between ...
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