94: Binding capacity of serum Testosterone-Estradiol Binding Globulin (TeBG) in males: Variations with age and pathological conditions

Abstract

y s t a t h i o n i n e and t a u r i n e i n human b r a i n d u r i n g e a rl y f o e t a l development.The d e v e l o p m e n t a l changes i n t h e c o n c e n t r a t i o n of L -c y s t a t h i o n i n e and t a u r i n e i n hunan f o e t a l b r a i n t i ss u e were examined d u r i n c t h e f i r s t and second t r i m e st e r , which i s t h e p e r i o d of i n t e n s i v e n e u r o n a l g r o w t h and m u l t i p l i c a t i o n . B r a i n t i s s u e s a m p l e s were o b t a ined from 14 f o e t u s e s ( crown-rump l e n g t h 2.5-21 cm ) a t l e g a l t h e r a p e u t i c a b o r t i o n s . T i s s u e specimens were i n . o e d i a t e l y p r e p a r e d f o r amino a c i d a n a l y s e s which were performed by a u t o m a t i c column chromatography. There was v i r t u a l l y no L -c y s t a t h i o n i n e i n .ih'ole-brain t i s s u e from t h e s m a l l e s t f o e t u s ( crown-rump l e n g t h 2 . 5 cm ) . Throughout t h e f i r s t and seconu t r i a l e s t e r a s t e a d y i n c r e a s e i n t h e c o n c e n t r a t i o n of L -c y s t a t h i on i n e o c c u r r e d i n f o e t a l b r a i n s . The amount of t a u r i n e was h i g h i n b r a i n t i s s u e from t h e s m a l l e s t f i r s t -t r im e s t e r f o e t u s : some i n c r e a s e o c c u r r e d j u r i n g f i r s t and second t r i m e s t e r . J u r i n g e a r l y f o e t a l development t h e c o n c e r i t r a t i o n of t a u r i n e i n hunan b r a i n was h i g he r t h a n p r e v i o u s l y r e p o r t e d amounts d u r i n g p e r i n a t a l p e r i o d and a d u l t l i f e . The d i s t r i b u t i o n of L -c y s t at h i o n i n e and t a u r i n e i n b r a i n t i s s u e d u r i n g l a t e mi3-t r i m e s t e r d i f f e r e d from t h a t o b s e r v e d i n a d u l t hunans. bv H.K.A. V i s s e r ) . "La F e " C h i l d r e n ' s Hosp i t a l V a l e n c i a , S p a i n .~n t r a u t e r i n e bone growth. At b i r t h , growth and m a t u r a t i o n of t h e newborn a r e u s u a l l y a s s e s s e d by c l i n i c a l , a n t h r o p o m e t r i c and neurol o g i c a l e x a m i n a t i o n s . A new q u a n t i t a t i v e and o b j e c t i v e method i s p r e s e n t e d : t h e l e n g t h of c u b i t u s and r a d i u s . A t o t a l of 156 newborns, 75 m a l e s and 81 f e m a l e s a p p r o p i a t e f o r g e s t a t i o n a l a g e (AGE), from t h e 2 4 t h t h r o u g h t h e 4 0 t h week of g e s t a t i o n w e r e s t u d i e d . Three i n d e p e n d e n t i n v e s t i g a t o r s p a r t i c i p a t e d i n t h e c o l l e c t i o n of t h e d a t a , o n l y one of them, by n e c e s it y , knew t h e d a t e of t h e l a s t m e n s t r u a l p e r i o d . Bone l e n g t h was measured by a "DIAL CALIPER HELIOS" w i t h a s e n s i t i v i t y of m e t e r s . Bone growth i n l e n g t h from t h e 24th t h r o u g h t h e 4 0 t h week i s a li n e a r f u n c t i o n w i t h a p p a r e n t l y two d i f f e r e n t s l o p e s , one between ...

Hypothalamo‐pituitary‐gonadal Function in Male Central Precocious Puberty

“…In normal boys, the pubertal increase of plasma testosterone is concomitant with a significant fall of the TeBG binding capacity of serum (Vermeulen et al, 1969;Georges et al, 1976). Recent data from this laboratory show that this decrease of the TeBG binding capacity occurs very early in the chronology of normal puberty (Fig.…”